Immune Thrombocytopenia and Obesity: Predictive Relationship.
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Journal: 2017/August - Ochsner Journal
ISSN: 1524-5012
PUBMED: 28331458
Abstract:
BACKGROUND
Chronic refractory immune thrombocytopenia (ITP) is defined as the failure of any modality to maintain the platelet count above 20 × 103/μL for an appreciable time without unacceptable toxicity. To date, certain predictive factors have been associated with refractory ITP. However, none of the published studies has declared the possible association between obesity and refractory ITP.
METHODS
We present the cases of 3 children with ITP who failed to achieve remission on different therapeutic approaches including rituximab, vincristine, and romiplostim. The 3 children had obesity as a common feature.
CONCLUSIONS
We present these cases to propose a possible association between obesity and refractoriness of ITP to different therapeutic approaches and to emphasize the need for further study to establish whether a causal relationship exists.
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Ochsner J 17(1): 115-117
PMID: 28331458

Immune Thrombocytopenia and Obesity: Predictive Relationship

Prince Sultan Oncology Center, King Salman Armed Forces Hospital, Tabuk, Kingdom of Saudi Arabia
Address correspondence to Ehab Hanafy, MD, Prince Sultan Oncology Center, King Salman Armed Forces Hospital, 71411 Tabuk, Kingdom of Saudi Arabia. Tel: +966-50-329-8454. Email: moc.liamg@duomhamh.bahe
Copyright © Academic Division of Ochsner Clinic Foundation

Abstract

Background:

Chronic refractory immune thrombocytopenia (ITP) is defined as the failure of any modality to maintain the platelet count above 20 × 10/μL for an appreciable time without unacceptable toxicity. To date, certain predictive factors have been associated with refractory ITP. However, none of the published studies has declared the possible association between obesity and refractory ITP.

Case Reports:

We present the cases of 3 children with ITP who failed to achieve remission on different therapeutic approaches including rituximab, vincristine, and romiplostim. The 3 children had obesity as a common feature.

Conclusion:

We present these cases to propose a possible association between obesity and refractoriness of ITP to different therapeutic approaches and to emphasize the need for further study to establish whether a causal relationship exists.

Keywords: Pediatric obesity, purpura–thrombocytopenic–idiopathic
Abstract

ACKNOWLEDGMENTS

The authors have no financial or proprietary interest in the subject matter of this article.

ACKNOWLEDGMENTS

REFERENCES

REFERENCES

References

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