This review will discuss the uses of avian models, particularly the chicken, to examine nutrition-endocrine interactions. The chicken has been employed extensively to examine nutritional effects. The effects of fasting, protein deficiency and calcium deficiency on endocrine status have been the subject of intense investigation in young chicks and adult female chickens. The ratio of circulating concentrations of triiodothyronine (T3) and thyroxine (T4) is substantially changed by fasting or protein deficiency. Similarly, protein deficiency reduces circulating concentrations of insulin-like growth factor I (IGFI) while protein deficiency increases growth hormone (GH). Moreover, protein deficiency increases the sensitivity and responsiveness of adrenocortical cells. The chicken also as advantages for studying diabetes, endocrine pancreatic functioning due to the splenic lobe of the pancreas being predominantly endocrine in nature, and the cellular mechanism of GH on chicken adipose tissue. The adult female chicken with its high calcium requirement is a unique system for examining nutritional effects on reproduction.