J Physiol 193(2): 443-453
Effects of adrenaline on human blood platelets
Abstract
1. Adrenaline at concentrations too low to cause aggregation of human platelets potentiates the aggregation by adenosine diphosphate. Noradrenaline has the same effect but is less active than adrenaline; isopropylnoradrenaline is inactive or inhibitory.
2. The potentiation of adenosine diphosphate by catecholamines is blocked by the adrenergic α-receptor antagonists phentolamine and dihydroergotamine but not by 2-halogenoethylamines or by adrenergic β-receptor antagonists.
3. Both the first and second phases of adenosine diphosphate aggregation are potentiated by catecholamines but the second phase more than the first.
4. The release from the platelets of adenine nucleotides which is associated with the second phase of aggregation is also increased by adrenaline.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1013K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ardlie NG, Glew G, Schwartz CJ. Influence of catecholamines on nucleotide-induced platelet aggregation. Nature. 1966 Oct 22;212(5060):415–417. [PubMed] [Google Scholar]
- Besterman E, Myat G, Travadi V. Diurnal variations of platelet stickiness compared with effects produced by adrenaline. Br Med J. 1967 Mar 11;1(5540):597–600.[PMC free article] [PubMed] [Google Scholar]
- BOHR DF. ELECTROLYTES AND SMOOTH MUSCLE CONTRACTION. Pharmacol Rev. 1964 Mar;16:85–127. [PubMed] [Google Scholar]
- BORN GV. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature. 1962 Jun 9;194:927–929. [PubMed] [Google Scholar]
- BORN GV, CROSS MJ. EFFECTS OF INORGANIC IONS AND OF PLASMA PROTEINS ON THE AGGREGATION OF BLOOD PLATELETS BY ADENOSINE DIPHOSPHATE. J Physiol. 1964 Mar;170:397–414.[PMC free article] [PubMed] [Google Scholar]
- Born GV, Mills DC, Roberts GC. Potentiation of platelet aggregation by adrenaline. J Physiol. 1967 Jul;191(1):43P–44P. [PubMed] [Google Scholar]
- Bull BS, Zucker MB. Changes in platelet volume produced by temperature, metabolic inhibitors, and aggregating agents. Proc Soc Exp Biol Med. 1965 Nov;120(2):296–301. [PubMed] [Google Scholar]
- Constantine JW. Aggregation of guinea-pig platelets by adenosine diphosphate. Nature. 1966 Apr 9;210(5032):162–164. [PubMed] [Google Scholar]
- FURCHGOTT RF. The pharmacology of vascular smooth muscle. Pharmacol Rev. 1955 Jun;7(2):183–265. [PubMed] [Google Scholar]
- FURCHGOTT RF. The receptors for epinephrine and norepinephrine (adrenergic receptors). Pharmacol Rev. 1959 Jun;11(2 Pt 2):429–442. [PubMed] [Google Scholar]
- GAZES PC, RICHARDSON JA, WOODS EF. Plasma catechol amine concentrations in myocardial infarction and angina pectoris. Circulation. 1959 May;19(5):657–661. [PubMed] [Google Scholar]
- GRAHAM JD. DISTRIBUTION OF (2-BROMOETHYL)ETHYL(NAPHTH-1-YMETHYL-(14C))AMINE HYDROBROMIDE IN THE RAT. Br J Pharmacol Chemother. 1964 Oct;23:285–294.[PMC free article] [PubMed] [Google Scholar]
- HASLAM RJ. ROLE OF ADENOSINE DIPHOSPHATE IN THE AGGREGATION OF HUMAN BLOOD-PLATELETS BY THROMBIN AND BY FATTY ACIDS. Nature. 1964 May 23;202:765–768. [PubMed] [Google Scholar]
- HOLMSEN H. COLLAGEN-INDUCED RELEASE OF ADENOSINE DIPHOSPHATE FROM BLOOD PLATELETS INCUBATED WITH RADIOACTIVE PHOSPHATE IN VITRO. Scand J Clin Lab Invest. 1965;17:239–246. [PubMed] [Google Scholar]
- Holmsen H, Holmsen I, Bernhardsen A. Microdetermination of adenosine diphosphate and adenosine triphosphate in plasma with firefly luciferase system. Anal Biochem. 1966 Dec;17(3):456–473. [PubMed] [Google Scholar]
- HOLZBAUER M, VOGT M. The concentration of adrenaline in the peripheral blood during insulin hypoglycaemia. Br J Pharmacol Chemother. 1954 Jun;9(2):249–252.[PMC free article] [PubMed] [Google Scholar]
- HOVIG T. RELEASE OF A PLATELET-AGGREGATING SUBSTANCE (ADENOSINE DIPHOSPHATE) FROM RABBIT BLOOD PLATELETS INDUCED BY SALINE "EXTRACT" OF TENDONS. Thromb Diath Haemorrh. 1963 Jul 15;143:264–278. [PubMed] [Google Scholar]
- Howe R, Shanks RG. Optical isomers of propranolol. Nature. 1966 Jun 25;210(5043):1336–1338. [PubMed] [Google Scholar]
- Jenkinson DH, Morton IK. The role of alpha- and beta- adrenergic receptors in some actions of catecholamines on intestinal smooth muscle. J Physiol. 1967 Feb;188(3):387–402.[PMC free article] [PubMed] [Google Scholar]
- KASER-GLANZMANN R, LUSCHER EF. The mechanism of platelet aggregation in relation to hemostasis. Thromb Diath Haemorrh. 1962 Jul 15;7:480–490. [PubMed] [Google Scholar]
- MCCLURE PD, INGRAM GI, JONES RV. PLATELET CHANGES AFTER ADRENALINE INFUSIONS WITH AND WITHOUT ADRENALINE BLOCKERS. Thromb Diath Haemorrh. 1965 Mar 15;13:136–139. [PubMed] [Google Scholar]
- McDONALD L, EDGILL M. Changes in coagulability of the blood during various phases of ischaemic heart-disease. Lancet. 1959 May 30;1(7083):1115–1118. [PubMed] [Google Scholar]
- Macmillan DC. Secondary clumping effect in human citrated platelet-rich plasma produced by adenosine diphosphate and adrenaline. Nature. 1966 Jul 9;211(5045):140–144. [PubMed] [Google Scholar]
- MITCHELL JR, SHARP AA. PLATELET CLUMPING IN VITRO. Br J Haematol. 1964 Jan;10:78–93. [PubMed] [Google Scholar]
- O'BRIEN JR. SOME EFFECTS OF ADRENALINE AND ANTI-ADRENALINE COMPOUNDS ON PLATELETS IN VITRO AND IN VIVO. Nature. 1963 Nov 23;200:763–764. [PubMed] [Google Scholar]
- O'BRIEN JR. A COMPARISON OF PLATELET AGGREGATION PRODUCED BY SEVEN COMPOUNDS AND A COMPARISON OF THEIR INHIBITORS. J Clin Pathol. 1964 May;17:275–281.[PMC free article] [PubMed] [Google Scholar]
- Sinakos Z, Caen J. Le comportement des plaquettes chez le rat. Thromb Diath Haemorrh. 1966 Jul 31;16(1):163–184. [PubMed] [Google Scholar]
- Thomas DP. Effect of catecholamines on platelet aggregation caused by thrombin. Nature. 1967 Jul 15;215(5098):298–299. [PubMed] [Google Scholar]
- WAUGH WH. Role of calcium in contractile excitation of vascular smooth muscle by epinephrine and potassium. Circ Res. 1962 Dec;11:927–940. [PubMed] [Google Scholar]