Hum Gene Ther Clin Dev 26(1): 15-26

Dog Models for Blinding Inherited Retinal Dystrophies

^{Department of Small Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824.}

^{Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.}

^{Corresponding author.}

Address correspondence to:, Dr. Simon Petersen-Jones, Department of Small Animal Clinical Sciences, Michigan State University, 736 Wilson Road, D-208, Veterinary Medical Center, East Lansing, MI 48824, E-mail:Email: ude.usm@513retep

Received 2014 Dec 17; Accepted 2014 Dec 26.

Abstract

Spontaneous canine models exist for several inherited retinal dystrophies. This review will summarize the models and indicate where they have been used in translational gene therapy trials. The RPE65 gene therapy trials to treat childhood blindness are a good example of how studies in dogs have contributed to therapy development. Outcomes in human clinical trials are compared and contrasted with the result of the preclinical dog trials.

Abstract

References

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