COCCIDIOIDOMYCOSIS—Treatment with Isonicotinic Acid Hydrazide
Abstract
Since coccidioidal granulomas are histologically indistinguishable from tuberculous granulomas, a long course of isonicotinic acid hydrazide therapy was tried experimentally in three cases of coccidioidomycosis, with good results. In two cases the disease was far advanced and prognosis poor before INH therapy was begun. In one case the disease was mild and symptoms abated after a short course of small doses of INH. It recurred when INH therapy was discontinued, and again resolved when larger doses of INH were given over a longer period.
INH seemed to have an effect on appetite also, although the patients were taking B-complex vitamins both before and during INH treatment. The three patients ill with coccidioidomycosis averaged a weight gain of four and a half pounds a month during the period of INH therapy. Six well persons who were underweight and lacked appetite were given INH without other drugs, and they then had an increase in appetite and in weight.
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- BIEHL JP, VILTER RW. Effect of isoniazid on vitamin B6 metabolism; its possible significance in producing isoniazid neuritis. Proc Soc Exp Biol Med. 1954 Mar;85(3):389–392. [PubMed] [Google Scholar]
- EDELSON E. Isoniazid in the treatment of chronic discoid lupus erythematosus; report of three cases. J Invest Dermatol. 1953 Jul;21(1):1–3. [PubMed] [Google Scholar]
- EDELSON E. Isoniazid in the treatment of sarcoidosis; a preliminary report. J Invest Dermatol. 1953 Aug;21(2):71–74. [PubMed] [Google Scholar]
- FIESE MJ, CHEU S, SORENSEN RH. Mycelial forms of Coccidioides immitis in sputum and tissues of the human host. Ann Intern Med. 1955 Aug;43(2):255–270. [PubMed] [Google Scholar]
- ISRAEL HL, SONES M, HARRELL D. Ineffectiveness of isoniazid and iproniazid in therapy of sarcoidosis. Am Rev Tuberc. 1953 May;67(5):671–673. [PubMed] [Google Scholar]
- LEVAN NE, BURGER CH. Coccidioidomycosis in dogs; a report of three cases. Calif Med. 1955 Nov;83(5):379–380.[PMC free article] [PubMed] [Google Scholar]
- MCVAY LV, Jr, SPRUNT DH. Treatment of actinomycosis with isoniazid. J Am Med Assoc. 1953 Sep 12;153(2):95–98. [PubMed] [Google Scholar]
- NORDEN A. Sporotrichosis; clinical and laboratory features and a serologic study in experimental animals and humans. Acta Pathol Microbiol Scand Suppl. 1951;89:1–119. [PubMed] [Google Scholar]
- SNAPPER I, BAKER LA, EDIDIN BD, KUSHNER DS. The results of 2-hydroxystilbamidine therapy in disseminated coccidioidomycosis. Ann Intern Med. 1955 Aug;43(2):271–286. [PubMed] [Google Scholar]
- TAGER M. The effect of isoniazid and iproniazid on Coccidioides immitis. Am Rev Tuberc. 1953 Apr;67(4):538–538. [PubMed] [Google Scholar]