Proc Natl Acad Sci U S A 68(9): 2112-2116
Clock Mutants of <em>Drosophila melanogaster</em>
Abstract
Three mutants have been isolated in which the normal 24-hour rhythm is drastically changed. One mutant is arrhythmic; another has a period of 19 hr; a third has a period of 28 hr. Both the eclosion rhythm of a population and the locomotor activity of individual flies are affected. All these mutations appear to involve the same functional gene on the X chromosome.
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- KARAKASHIAN MW, HASTINGS JW. The inhibition of a biological clock by actinomycin D. Proc Natl Acad Sci U S A. 1962 Dec 15;48:2130–2137.[PMC free article] [PubMed] [Google Scholar]
- Feldman JF. Lengthening the period of a biological clock in Euglena by cycloheximide, an inhibitor of protein synthesis. Proc Natl Acad Sci U S A. 1967 Apr;57(4):1080–1087.[PMC free article] [PubMed] [Google Scholar]
- Vanden Driessche T. The role of the nucleus in the circadian rhythms of Acetabularia mediterranea. Biochim Biophys Acta. 1966 Nov 8;126(3):456–470. [PubMed] [Google Scholar]
- Pye K, Chance B. Sustained sinusoidal oscillations of reduced pyridine nucleotide in a cell-free extract of Saccharomyces carlsbergensis. Proc Natl Acad Sci U S A. 1966 Apr;55(4):888–894.[PMC free article] [PubMed] [Google Scholar]
- CHANCE B, ESTABROOK RW, GHOSH A. DAMPED SINUSOIDAL OSCILLATIONS OF CYTOPLASMIC REDUCED PYRIDINE NUCLEOTIDE IN YEAST CELLS. Proc Natl Acad Sci U S A. 1964 Jun;51:1244–1251.[PMC free article] [PubMed] [Google Scholar]
- Pittendrigh CS. Circadian systems. I. The driving oscillation and its assay in Drosophila pseudoobscura. Proc Natl Acad Sci U S A. 1967 Oct;58(4):1762–1767.[PMC free article] [PubMed] [Google Scholar]
- Karakashian MW. The rhythm of mating in Paramecium aurelia, syngen 3. J Cell Physiol. 1968 Jun;71(3):197–209. [PubMed] [Google Scholar]
- Sargent ML, Briggs WR, Woodward DO. Circadian nature of a rhythm expressed by an invertaseless strain of Neurospora crassa. Plant Physiol. 1966 Oct;41(8):1343–1349.[PMC free article] [PubMed] [Google Scholar]
- Zimmerman WF, Pittendrigh CS, Pavlidis T. Temperature compensation of the circadian oscillation in drosophila pseudoobscura and its entrainment by temperature cycles. J Insect Physiol. 1968 May;14(5):669–684. [PubMed] [Google Scholar]
- Frank KD, Zimmerman WF. Action spectra for phase shifts of a circadian rhythm in Drosophila. Science. 1969 Feb 14;163(3868):688–689. [PubMed] [Google Scholar]
- Roberts SK. "Clock" Controlled Activity Rhythms in the Fruit Fly. Science. 1956 Jul 27;124(3213):172–172. [PubMed] [Google Scholar]
- Pittendrigh CS, Skopik SD. Circadian systems. V. The driving oscillation and the temporal sequence of development. Proc Natl Acad Sci U S A. 1970 Mar;65(3):500–507.[PMC free article] [PubMed] [Google Scholar]