J Physiol 289: 83-97
Charge movement and membrane capacity in frog muscle.
Abstract
1. The transient current required to impose a step charge of potential has a complex time course especially in the region of internal potential between -50 and -40 mV. 2. Examination of non-linear transient current in this voltage range suggests two components of charge movement: (a) an initial more-or-less exponential movement, and (b) a slower component with a complex time course. 3. Measurements of membrane capacity support such a division and confirm the steeper voltage dependence of the slower charge movement. 4. Permanent depolarization to 40 mV appears to immobilize the slowly moving charge. Depolarization to -20 mV immobilizes both charge movements, and uncovers the presence of a third charge which seems to correspond to Charge 2 (cf. Adrian & Almers, 1976b; Adrian, Chandler & Rakowski, 1976).
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Selected References
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- Adrian RH. Charge movement in the membrane of striated muscle. Annu Rev Biophys Bioeng. 1978;7:85–112. [PubMed] [Google Scholar]
- Adrian RH, Almers W. Membrane capacity measurements on frog skeletal muscle in media of low ion content. J Physiol. 1974 Mar;237(3):573–605.[PMC free article] [PubMed] [Google Scholar]
- Adrian RH, Almers W. The voltage dependence of membrane capacity. J Physiol. 1976 Jan;254(2):317–338.[PMC free article] [PubMed] [Google Scholar]
- Adrian RH, Almers W. Charge movement in the membrane of striated muscle. J Physiol. 1976 Jan;254(2):339–360.[PMC free article] [PubMed] [Google Scholar]
- Adrian RH, Chandler WK, Hodgkin AL. Voltage clamp experiments in striated muscle fibres. J Physiol. 1970 Jul;208(3):607–644.[PMC free article] [PubMed] [Google Scholar]
- Adrian RH, Chandler WK, Rakowski RF. Charge movement and mechanical repriming in skeletal muscle. J Physiol. 1976 Jan;254(2):361–388.[PMC free article] [PubMed] [Google Scholar]
- Adrian RH, Peres AR. A gating signal for the potassium channel? Nature. 1977 Jun 30;267(5614):800–804. [PubMed] [Google Scholar]
- Adrian RH, Rakowski RF. Reactivation of membrane charge movement and delayed potassium conductance in skeletal muscle fibres. J Physiol. 1978 May;278:533–557.[PMC free article] [PubMed] [Google Scholar]
- Almers W. Observations on intramembrane charge movements in skeletal muscle. Philos Trans R Soc Lond B Biol Sci. 1975 Jun 10;270(908):507–513. [PubMed] [Google Scholar]
- Almers W. Some dielectric properties of muscle membrane and their possible importance for excitation-contraction coupling. Ann N Y Acad Sci. 1975 Dec 30;264:278–292. [PubMed] [Google Scholar]
- Chandler WK, Rakowski RF, Schneider MF. A non-linear voltage dependent charge movement in frog skeletal muscle. J Physiol. 1976 Jan;254(2):245–283.[PMC free article] [PubMed] [Google Scholar]
- Chandler WK, Rakowski RF, Schneider MF. Effects of glycerol treatment and maintained depolarization on charge movement in skeletal muscle. J Physiol. 1976 Jan;254(2):285–316.[PMC free article] [PubMed] [Google Scholar]
- HODGKIN AL, HUXLEY AF. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol. 1952 Aug;117(4):500–544.[PMC free article] [PubMed] [Google Scholar]
- Hodgkin AL, Nakajima S. The effect of diameter on the electrical constants of frog skeletal muscle fibres. J Physiol. 1972 Feb;221(1):105–120.[PMC free article] [PubMed] [Google Scholar]
- Schneider MF, Chandler WK. Effects of membrane potential on the capacitance of skeletal muscle fibers. J Gen Physiol. 1976 Feb;67(2):125–163.[PMC free article] [PubMed] [Google Scholar]