Frequency of occurrence of strains of C. parapsilosis, their susceptibility to drugs and importance in pathogenesis of vaginal mycosis, was evaluated. Strains of C. parapsilosis were isolated in 44 cases which comprises 1.34% of a total number of 3275 tested Candida-like strains. Vaginal mycoses occurred in presence of Lactobacillus sp., normal pH values of vaginal contents, whereas leukocytosis was differing. Following drugs were used for testing susceptibility of C. parapsilosis: nystatin, pimaricin, amphotericin B, flucytosine, cotrimoxazole, miconazole, ketoconazole, tioconazole, fluconazole and itraconazole. It has been demonstrated that 38.3% strains of C. parapsilosis were exhibiting lowered activity toward amphotericin B, nystatin (23.5% resistant) and flucytosine (11.7% resistant). Tested strains were susceptible to remaining drugs within 94.1% and 100%.