Treated with orthodox therapy, a 58-year-old man with acute myocardial infarction of the anteroseptal and lateral walls continued having lethal arrhythmias, reinfarction, low blood pressure, and anuria. With modified neuroleptic analgesic therapy, which consisted only of a continuous drip injection of morphine and chlorpromazine, his condition improved dramatically. Our patient's coronary spasms, which occurred after acute myocardial infarction, might have been triggered by mental stress due to anxiety and pain, and the use of neuroleptic analgesic agent therapy prevented further coronary spasm and reinfarction.