Abstract:

The aerial parts of extensively used ethnomedicinal plant Mikania cordata (Burm. f.) Robinson growing wild in Bangladesh were investigated to isolate and characterize compounds responsible for the bioactivities of the plant. In the present study, a new derivatives of betulinic acid, 16-hydroxy betulinic acid [3β,16-dihydroxy-lup-20(29)-en-28-oic] was isolated and the structure of the compound was determined by NMR spectroscopic means and comparing with available literature data. The isolated compound was then investigated for different pharmacological activities including antibacterial, antifungal, analgesic, anti-inflammatory and antipyretic potential employing different methods. The compound showed potent antibacterial activity with inhibition zone of diameter ranging from 12.0 to 17.5 mm and antifungal activity with mycelial growth inhibition ranging from 37.6 to 54.5%. The MIC values for antibacterial and antifungal activities ranged from 31.5-125 and 250-1000 μg/mL respectively. The compound (50 and 100 mg/kg body weight) showed potent peripheral and central analgesic activity with 55.19% and 41% of writhing inhibition at 90 min after administration of the compound and the highest 55.98%, 79.18% elongation of reaction time, respectively. In anti-inflammatory activity screening, the compound (100 mg/kg b.w.) revealed the highest 77.08% edema inhibition at 4 h after administration of carrageenan. In antipyretic assay, 16-hydroxy betulinic acid displayed a strong antipyretic effect in yeast-induced rats. From the present study it is apparent that 16-hydroxy betulinic acid might play vital role to establish M. cordata as ethnomedicinal plant to treat wound, cuts and fever.

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A novel triterpenoid 16-hydroxy betulinic acid isolated from <em>Mikania cordata</em> attributes multi-faced pharmacological activities

^{Department of Applied Chemistry and Chemical Engineering, Islamic University, Kushtia 7003, Bangladesh}

^{Department of Botany, University of Dhaka, Dhaka 1000, Bangladesh}

^{Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka 1000, Bangladesh}

^{Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia}

^{Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia}

Atiqur Rahman: db.ca.ui.tcca@qita; M. Oliur Rahman: db.ca.ud@tob.ruilo

^{Corresponding authors.}db.ca.ui.tcca@qita, db.ca.ud@tob.ruilo

Atiqur Rahman: db.ca.ui.tcca@qita; M. Oliur Rahman: db.ca.ud@tob.ruilo

Received 2018 Jan 23; Revised 2018 Mar 3; Accepted 2018 Mar 4.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

EV: Edema volume. Values represent the mean ± S.E.M. (n = 5), ^{P < 0.05 and}^{P < 0.01 compared with control group.}

Values are mean ± S.E.M. rectal temperature (n = 5), ^{P < 0.05 and}^{P < 0.01 compared with control group.}

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Peer review under responsibility of King Saud University.

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