Biochem J 105(3): 971-978
14α-Hydroxyoestrone, a new oestrogen metabolite
Abstract
1. Incubation of oestrone with ox adrenal glands leads to the formation of two main metabolites, one of which has recently been identified as 15α-hydroxyoestrone; the second metabolite (Oe-5) has now been obtained in crystalline form and identified as the hitherto unknown 14α-hydroxyoestrone. 2. The identity of compound Oe-5 with 14α-hydroxyoestrone was confirmed conclusively by comparison with 14α-hydroxyoestrone that was synthesized by pyrolytic aromatization of 14α-hydroxyandrosta-1,4-diene-3,17-dione. 3. The physical and chemical properties as well as the oestrogenic activity of 14α-hydroxyoestrone are described. 4. The biogenesis and metabolism of 14α-hydroxyoestrone were studied in various tissue preparations.
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- BREUER H, NOCKE L, KNUPPEN R. Reduktion von 16 alpha-Hydroxy-oestron und 16-Keto-oestradiol-(17 beta) durch menschliches Lebergewebe in vitro. Hoppe Seylers Z Physiol Chem. 1958;311(4-6):275–278. [PubMed] [Google Scholar]
- KNUPPEN R, BREUER H. Biogenesis of 11beta-hydroxyoestrone and 16alpha-hydroxyoestrone by adrenal tissue. Biochim Biophys Acta. 1962 Mar 26;58:147–148. [PubMed] [Google Scholar]
- KNUPPEN R, BREUER H. 15-ALPHA-HYDROXYLIERUNG VON OSTRON IN DER NEBENNIERE. Hoppe Seylers Z Physiol Chem. 1964;337:159–160. [PubMed] [Google Scholar]
- KNUPPEN R, BEHM M, BREUER H. BIOGENESE VON 6-ALPHA-HYDROXY-OESTRON IN DER NEBENNIERE. Hoppe Seylers Z Physiol Chem. 1964;337:145–149. [PubMed] [Google Scholar]
- Knuppen R, Haupt M, Breuer H. Formation of 15-alpha-hydroxyoestradiol-17-beta and 18-hydroxyoestrone by human adrenal tissue. J Endocrinol. 1965 Nov;33(3):529–530. [PubMed] [Google Scholar]
- Knuppen R, Haupt O, Breuer H. The isolation of 6-alpha-hydroxyoestrone from the urine of pregnant women. Biochem J. 1966 Nov;101(2):397–401.[PMC free article] [PubMed] [Google Scholar]
- LOKE KH, MARRIAN GF, WATSON EJ. The isolation of a sixth Kober chromogen from the urine of pregnant women and its identification as 18-hydroxyoestrone. Biochem J. 1959 Jan;71(1):43–48.[PMC free article] [PubMed] [Google Scholar]
- LOKE KH, WATSON EJ, MARRIAN GF. The isolation of a sixth Kober chromogen from the urine of pregnant women and its provisional identification as 18-hydroxyoestrone. Biochim Biophys Acta. 1957 Oct;26(1):230–231. [PubMed] [Google Scholar]
- MITCHELL FL, DAVIES RE. The isolation and estimation of the steroid oestrogens in placental tissue. Biochem J. 1954 Apr;56(4):690–698.[PMC free article] [PubMed] [Google Scholar]
- NOCKE W. A study of the colorimetric estimation of oestradiol-17 beta, oestradiol-17 alpha, oestrone, oestriol and 16-epioestriol by the Kober reaction. Biochem J. 1961 Mar;78:593–602.[PMC free article] [PubMed] [Google Scholar]