Vimovo contains a combination of ,esomeprazole, and ,naproxen,. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing substances in the body that cause inflammation, pain, and fever.Esomeprazole is a ,proton pump inhibitor,. It is included in Vimovo to decrease the amount of acid produced in the stomach.Vimovo is used to treat symptoms of osteoarthritis, rheumatoid arthritis, juvenile idiopathic arthritis, and ankylosing spondylitis. The esomeprazole in this medicine helps reduce the risk of stomach ulcers in people who may be at risk for them while receiving treatment with an NSAID.