Last Verified: | June/30/2020 |
First Submitted: | July/6/2020 |
Estimated Enrollment Submitted: | July/13/2020 |
First Posted: | July/16/2020 |
Last Update Submitted: | July/13/2020 |
Last Update Posted: | July/16/2020 |
Actual Study Start Date: | June/30/2020 |
Estimated Primary Completion Date: | June/30/2028 |
Estimated Study Completion Date: | June/30/2028 |
Study Type: | Interventional |
Allocation: | Randomized |
: | single blind controlled trial |
Primary Purpose: | Treatment |
Masking: | Single (Participant) |
Arm | Intervention/treatment |
---|---|
Active Comparator: Sevoflurane group patients in this group will receive inhalation anaesthesia with sevoflurane at Minimal Alveolar Concentration 0.7-1.3 as the main anaesthetic to achieve Bispectral Index 40-60. Other anaesthetic management will be standardised. | Drug: Sevoflurane group sevoflurane at Minimal Alveolar Concentration 0.7-1.3 as the main anaesthetic to achieve Bispectral Index 40-60. |
Active Comparator: propofol group patients in this group will receive intravenous propofol using Target Controlled Infusion 'Paedfusor' model 2-5 as the main anaesthetic to achieve Bispectral Index 40-60. Other anaesthetic management will be standardised. | Drug: propofol group intravenous propofol using Target Controlled Infusion 'Paedfusor' model 2-5 as the main anaesthetic to achieve Bispectral Index 40-60 |
Ages Eligible for Study: | 6 Months to 6 Months |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Criteria: | Inclusion Criteria: - patients coming for elective primary solid tumor resection for curative intent in Hong Kong Children's Hospital - AND patients > 5kg - AND patients within age limit Exclusion Criteria: - Autoimmune / Chronic inflammatory diseases e.g. Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA) etc. - Current Steroid therapy - Surgery for tumour removal in the past year - Allergy to Propofol - intraoperative use of nitrous oxide - Patient susceptible to Malignant Hyperthermia - Patients / parents / legal guardians showing preference in anaesthetic techniques during recruitment process |