Listeria monocytogenes is a food safety challenge in various food systems including fresh and frozen meat and poultry. Natural antimicrobials from plant sources in combination with salts of organic acids have the potential to control L. monocytogenes. In this research the efficiency of water soluble phenolic extracts of oregano and cranberry in combination with sodium lactate was evaluated for control of L .monocytogenes. In both broth and cooked meat studies, the results indicated that the combination of water soluble extracts of oregano and cranberry, at a ratio of 50:50 and a concentration of 750 ppm, with 2% sodium lactate had the best inhibitory effect in the tested strain. Based on the rationale that phenolics in oregano and cranberry behave as proline analogs, the potential recovery of pathogen growth in medium with the best inhibitor concentration and supplemented with 1 mM proline was evaluated. The results indicated that there was a proline-induced growth recovery, pointing to a possible mechanism of action of inhibitors, involving proline metabolism. These results confirm the potential of plant extracts to be antimicrobial, and when combined with sodium lactate, can be used as a nature constituent of multiple-barrier food preservation systems.