Cadmium (Cd) has already caused worldwide concern because of its high biotoxicity to human and plants. This study investigated how nitrogen (N) and phosphorus (P) enrichment alter the toxic morpho-physiological impacts of and accumulation of Cd in hydroponically grown Salix matsudana Koidz cuttings. Our results showed that Cd significantly depressed growth and induced a physiological response on S. matsudana cuttings, exhibiting by reduced biomass, decreased photosynthetic pigment concentrations, and increased soluble protein and peroxidase activity of shoots and roots. N and P enrichment alleviated the Cd toxic effects by increasing production of proline which prevented cuttings from damage by Cd-induced ROS, displaying with decreased malondialdehyde concentration, and stimulated overall Cd accumulation. Enrichment of N and P significantly decreased the upward Cd transfer, combing with enhanced root uptake (stimulated root activity) and retranslocation from stem, resulted in extensive Cd sequestration in S. matsudana roots. In both root and xylem, concentration of Cd is positively correlated with N and P. The improved phytoextraction potential by N and P enrichment was mainly via elevating Cd concentration in roots, probably by increased production of phytochelatins (e.g., proline) which form Cd chelates and help preventing damage from Cd-induced ROS. This study provides support for the application of S. matsudana in Cd phytoextraction even in eutrophic aquatic environments.