Letter to the Editors: Additional Factors to Consider When Studying Liver Injury Indicators and Mortality in COVID-19 Patients
Journal: 2020/July - Hepatology
Abstract:
In a recent issue of Hepatology, Lei et al.(1) conducted a multicenter retrospective cohort study that included 5,771 adult patients with coronavirus disease 2019 (COVID-19) pneumonia in Hubei Province. The purpose of the study was to evaluate the relationships between liver injury indicators (alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase [ALP], and total bilirubin [TBIL]) and mortality in COVID-19 patients. The authors considered the possibility that elevated liver injury indicators, particularly AST, are strongly associated with mortality risk. However, the association between liver injury indicators and mortality in COVID-19 patients should be interpreted cautiously in light of the following issues.
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Letter to the Editors: Additional Factors to Consider When Studying Liver Injury Indicators and Mortality in COVID‐19 Patients

Department of Clinical Laboratory, Ningbo First Hospital, Ningbo Zhejiang, China,
Yanqing Liu, Email: moc.621@9891gniqnayuil.
Corresponding author.
Address correspondence and reprint requests to: Yanqing Liu, M.D.
Department of Clinical Laboratory, Ningbo First Hospital, 59 Liuting Street, Ningbo, 315010 Zhejiang, China
E‐mail: moc.621@9891gniqnayuil,
This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
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