Biochemical and histological effects of feeding thermally oxidized rapeseed oil and lard to rats.
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Journal: 1977/March - Canadian journal of comparative medicine : Revue canadienne de medecine comparee
ISSN: 0008-4050
PUBMED: 832196
Abstract:
Four groups of weanling rats were fed semisynthetic diets containing 15 percent by weight of dietary fats for 28 days. Two groups received thermally oxidized low-erucic acid rapeseed oil (OLE) or lard (OLA) and the other two groups received the respective fresh fats (FLE, FLA) as controls. Average daily feed consumption and feed efficiency were not affected by either OLE or OLA, however final body weights were depressed by the OLA in the diet. The relative heart weights and heart total lipids were significantly increased in both the OLE and OLA groups. A majority of the animals in both the OLE and OLA groups exhibited various gross symptoms attributable to heated fat toxicity such as seborrhea, diarrhea and polyuria. Excessive hair loss was noted in all the animals fed the heated fats. Tissue fatty acid changes due to OLA were confined largely to the polar liver lipids, whereas OLE produced dramatic changes in both the neutral heart lipids as well as in the neutral and polar liver lipids. Histological evaluation of the hearts, livers and kidneys indicated that OLA was very injurious to the kidneys, whereas OLE caused greater damage to both the hearts and livers.
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Can J Comp Med 41(1): 98-106
PMID: 832196

Biochemical and histological effects of feeding thermally oxidized rapeseed oil and lard to rats.

Abstract

Four groups of weanling rats were fed semisynthetic diets containing 15 percent by weight of dietary fats for 28 days. Two groups received thermally oxidized low-erucic acid rapeseed oil (OLE) or lard (OLA) and the other two groups received the respective fresh fats (FLE, FLA) as controls. Average daily feed consumption and feed efficiency were not affected by either OLE or OLA, however final body weights were depressed by the OLA in the diet. The relative heart weights and heart total lipids were significantly increased in both the OLE and OLA groups. A majority of the animals in both the OLE and OLA groups exhibited various gross symptoms attributable to heated fat toxicity such as seborrhea, diarrhea and polyuria. Excessive hair loss was noted in all the animals fed the heated fats. Tissue fatty acid changes due to OLA were confined largely to the polar liver lipids, whereas OLE produced dramatic changes in both the neutral heart lipids as well as in the neutral and polar liver lipids. Histological evaluation of the hearts, livers and kidneys indicated that OLA was very injurious to the kidneys, whereas OLE caused greater damage to both the hearts and livers.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Charlton KM, Corner AH, Davey K, Kramer JK, Mahadevan S, Sauer FD. Cardiac lesions in rats fed rapeseed oils. Can J Comp Med. 1975 Jul;39(3):261–269.[PMC free article] [PubMed] [Google Scholar]
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  • Michael WR, Alexander JC, Artman NR. Thermal reactions of methyl linoleate. I. Heating conditions, isolation techniques, biological studies and chemical changes. Lipids. 1966 Sep;1(5):353–358. [PubMed] [Google Scholar]
  • MORRISON WR, SMITH LM. PREPARATION OF FATTY ACID METHYL ESTERS AND DIMETHYLACETALS FROM LIPIDS WITH BORON FLUORIDE--METHANOL. J Lipid Res. 1964 Oct;5:600–608. [PubMed] [Google Scholar]
  • Poling CE, Eagle E, Rice EE, Durand AM, Fisher M. Long-term responses of rats to heat-treated dietary fats. IV. Weight gains, food and energy efficiencies, longevity and histopathology. Lipids. 1970 Jan;5(1):128–136. [PubMed] [Google Scholar]
Copyright notice
Abstract
Four groups of weanling rats were fed semisynthetic diets containing 15 percent by weight of dietary fats for 28 days. Two groups received thermally oxidized low-erucic acid rapeseed oil (OLE) or lard (OLA) and the other two groups received the respective fresh fats (FLE, FLA) as controls. Average daily feed consumption and feed efficiency were not affected by either OLE or OLA, however final body weights were depressed by the OLA in the diet. The relative heart weights and heart total lipids were significantly increased in both the OLE and OLA groups. A majority of the animals in both the OLE and OLA groups exhibited various gross symptoms attributable to heated fat toxicity such as seborrhea, diarrhea and polyuria. Excessive hair loss was noted in all the animals fed the heated fats. Tissue fatty acid changes due to OLA were confined largely to the polar liver lipids, whereas OLE produced dramatic changes in both the neutral heart lipids as well as in the neutral and polar liver lipids. Histological evaluation of the hearts, livers and kidneys indicated that OLA was very injurious to the kidneys, whereas OLE caused greater damage to both the hearts and livers.
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