Anti-inflammatory activity of date palm seed by downregulating interleukin-1β, TGF-β, cyclooxygenase-1 and -2: A study among middle age women
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Journal: 2020/August - Saudi Pharmaceutical Journal
Abstract:
The prevalence of degenerative diseases increases with age. Furthermore, various factors tend to trigger cells injury, thereby, causing inflammation. This study, therefore, aims to examine the anti-inflammatory mechanisms of steeping date seeds in middle age women. This is a quasi-experimental design with a pre- and post-test approach used to evaluate the anti-inflammatory effect of 2.5 g of steeped of date palm seed, consumed by 30 healthy middle-aged women per day (in 250 mL water) for 14 days. The final numbers (22 subjects) of recruited women were included in the statistical analysis. Their level of IL-1β, TGF-β, IL-6, TNF-α, IL-12, COX-1, COX-2, and PGE2 were determined using ELISA. The results showed that the expression of IL-1β, TGF-β, COX-1, and COX-2 in women significantly decreased after consuming date palm seed. Steeped of date seed acts as an anti-inflammatory by downregulating the expression of key proinflammatory mediators.
Keywords: Date palm seeds; Middle age women; Proinflammatory mediators.
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Saudi Pharm J 28(8): 1014-1018
PMID: 32792846

Anti-inflammatory activity of date palm seed by downregulating interleukin-1β, TGF-β, cyclooxygenase-1 and -2: A study among middle age women

Declaration of Competing Interest

The authors declared that there is no conflict of interest.

School of Nursing, Faculty of Health Sciences, University of Jenderal Soedirman, Purwokerto, Indonesia
School of Pharmacy, Faculty of Health Sciences, University of Jenderal Soedirman, Purwokerto, Indonesia
Saryono: di.ca.deosnu@6102onoyras
Corresponding author at: Karangwangkal, Purwokerto Utara, Banyumas Regency, Central Java 53123, Indonesia. di.ca.deosnu@6102onoyras
Received 2020 Apr 25; Accepted 2020 Jun 30.
Copyright © 2020 The Author(s)
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Peer review under responsibility of King Saud University.

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