The human Equilibrative Nucleoside Transporter 1 (hENT1) mediates the cellular uptake of physiologic nucleosides, including adenosine, as well as many anti-cancer drugs including gemcitabine, cytarabine, and decitabine. De ciency of hENT1 can lead to resistance of such drugs, and the abundance of hENT1 protein in the plasma membrane is a major indicator of the e ciency and clinical outcome of these anti-cancer nucleosides.
Positive control:Adrenal Cortex; Kidney; Thyroid; Tonsil; Normal Pancreas