c-Myc is a phosphoprotein involved with cell proliferation and differentiation. It is a useful marker for differentiation between Burkitt Lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) since, despite morphologically similarities between the two B-cell lymphomas Anti-c-Myc stains all BL and only a few DLBCL cases. A panel of antibodies against c-Myc, CD10, BCL2, and Ki-67 is useful for cases where MYC FISH analysis is warranted or can be omitted. Nuclear c-Myc overexpression is common in luminal cells of prostate intraepithelial neoplasia, many primary carcinomas, and metastatic disease.