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0.1ml C
IHC409-1000.1ml C -$165.00
IHC409-11ml C -$635.00
IHC409-77ml P -$465.00
IHC409-2525ml P -$1,395.00
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DNA mismatch repair protein MLH1
Synonyms: MutL protein homolog 1; Post meiotic segregation protein 2; MLH1_YEAST; D6VZY9; P38920; Q2I028; Q2I029; Q2I031; Q2I032; Q2I033; Q2I034; Q2I035; Q2I036; Q2I038; Q2I039; Q2I041
MutL Homolog 1 (MLH1) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, as the MLH1 gene is frequently mutated in patients with this cancer. Studies have shown MLH1 to be deficient in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MLH1 is optimized when paired in an IHC panel with MSH6, MSH2, and PMS2. Anti-MLH1 is useful in the detection of MLH1 in a number of normal and neoplastic tissues, and for identifying a loss of MLH1 in tumors that are microsatellite-unstable.
Positive control:Colon; Colon Carcinoma
Dilution range:1:100 - 1:200
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