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0.1ml C
IHC621-1000.1ml C -$210.00
IHC621-11ml C -$980.00
IHC621-77ml P -$520.00
RIDACOM Ltd. hotline:
Phosphatidylcholine translocator ABCB4
Synonyms: ATP-binding cassette sub-family B member 4; Multidrug resistance protein 3; P-glycoprotein 3; MDR3_HUMAN; A0A2V7; A4D1D3; A4D1D4; A4D1D5; D6W5P3; D6W5P4; P21439; Q14813
Multidrug Resistance 3 (MDR3), also known as ATP Binding Cassette Subfamily B Member 4 (ABCB4), is a membrane-associated protein belonging to the superfamily of ATP-binding cassette transporters. MDR3 is an energy-dependent phospholipid efflux translocator that mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte, and also acts as a positive regulator of biliary lipid secretion. Defects in MDR3 are associated with progressive familial intrahepatic cholestasis type 3 and gallbladder disease type 1. Co-overexpression of MDR3 and MRP1 has been documented as correlating with blastemal subtype and high-risk prognosis of Wilms’ tumor patients.
Positive control:Adrenal Cortex
Dilution range:1:100 - 1:200
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