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0.1ml C
IHC008-1000.1ml C -$180.00
IHC008-11ml C -$1,060.00
IHC008-77ml P -$270.00
IHC008-2525ml P -$810.00
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Paired box protein Pax-8
Synonyms: PAX8_CANLF; P47240; P47241
PAX-8 is a member of the paired box (PAX) family of transcription factors, which are key regulators in early development. This protein plays a role in development of thyroid follicular cells and the expression of thyroid-specific genes, with mutations in the PAX-8 gene linked to thyroid follicular carcinomas, atypical thyroid adenomas, and thyroid dysgenesis. The PAX-8 protein is expressed in simple ovarian inclusion cysts and non-ciliated mucosal cells of the fallopian tubes, but is absent from normal ovarian surface epithelial cells. PAX-8 is also not expressed in normal lung or lung carcinomas. Reports have associated PAX-8 expression with renal carcinoma, nephroblastoma, and seminoma, and have indicated PAX-8 as a useful marker for renal epithelial tumors, ovarian cancer, and for differential diagnoses in lung and neck tumors. Anti-PAX-8 can be useful in determining the primary site of invasive micropapillary carcinomas of ovary from bladder, lung, and breast, when used in adjunct with a panel of organ-specific markers such as uroplakin, mammaglobin, and TTF-1.
Positive control:Ovarian Carcinoma (Non-Mucinous Carcinoma); Thyroid Carcinoma; Renal Cell Carcinoma
Dilution range:1:100 - 1:200
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