Name: Phospho-GRK2(Ser29) Antibody
Brand: Affinity Biosciences
Price: 280 USD

AF2309

$280.00

100μl

	100μl -	$280.00
	200μl -	$350.00

RIDACOM Ltd. hotline:

+3592 955 99 98

info@ridacom.com

Phospho-GRK2(Ser29) Antibody

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Western blot analysis of extracts of Ramos cells, using Phospho-GRK2(Ser29) Antibody....

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AF2309 at 1/100 staining Human thyroid cancer tissue by IHC-P. The sample was formaldehyde fixed...

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ELISA analysis of AF2309 showing specificity to Phospho-GRK2(Ser29) peptide. Peptides concentration:...

Antigen:

Beta-adrenergic receptor kinase 1

Synonyms: G-protein coupled receptor kinase 2; ARBK1_HUMAN; B0ZBE1; P25098; Q13837; Q6GTT3

BioSeek|Uniprot

Host:Rabbit

Reactivity:Human; Mouse; Rat

Application:Western Blotting; Immunohistochemistry

Isotype:IgG

Clonality:Polyclonal

Aliases:ADRBK1; Adrenergic beta receptor kinase 1; ARBK1_HUMAN; BARK; BARK1; Beta adrenergic receptor kinase 1; Beta ARK 1; Beta ARK1; Beta-adrenergic receptor kinase 1; Beta-ARK-1; FLJ16718; G protein coupled receptor kinase 2; G-protein coupled receptor kinase 2; GRK2

Description:

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).

Purification:The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Concentration:1mg/ml

Buffer form:Liquid

Storage buffer:Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ¡ãC.Stable for 12 months from date of receipt

Specificity:

Phospho-GRK2(Ser29) Antibody detects endogenous levels of GRK2.

Storage conditions:Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Product specifications