Clusterin/Apolipoprotein J is normally found in epithelial cells, semen, plasma, breast milk, cerebrospinal fluid, and urine, and is involved in apoptosis and the clearance of cellular debris. It is present in hematopoietic and non-hematopoietic cancers, as well as most systemic anaplastic large cell lymphomas. Anti-Clusterin/Apolipoprotein J in a panel with other antibodies is useful for differentiating systemic anaplastic large cell lymphoma from classical Hodgkin's disease. Anti-Clusterin/Apolipoprotein J also displays high sensitivity and specificity for follicular dendritic cell tumors. Clusterin overexpression is linked to recurrence and poor prognosis in breast cancer, and chemosensistivity and poor survival in cervical cancer.
Positive control:Tonsil; Lymph Node; Placenta; Colon; Kidney; Brain and Liver