Affinity Biosciences
AF3431
$280.00
100μl
| 100μl - | $280.00 | |
| 200μl - | $350.00 |
Phospho-4E-BP1 (Thr36) Antibody
Western blot analysis of Phospho-4E-BP1 (Thr36) expression in various lysates
AF3431 at 1/100 staining human pancreas tissue sections by IHC-P. The tissue was formaldehyde...
AF3431 staining Hela by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton...
Antigen:
Eukaryotic translation initiation factor 4E-binding protein 1
Synonyms: Phosphorylated heat- and acid-stable protein regulated by insulin 1; 4EBP1_HUMAN; B2R502; D3DSW8; Q13541; Q6IBN3
Host:Rabbit
Reactivity:Human; Mouse; Rat
Application:Western Blotting; Immunohistochemistry; ELISA
Isotype:IgG
Clonality:Polyclonal
Aliases:4E-BP1; 4EBP1; 4EBP1_HUMAN; BP 1; eIF4E binding protein 1; eIF4E-binding protein 1; Eif4ebp1; Eukaryotic translation initiation factor 4E-binding protein 1; PHAS-I; PHASI; Phosphorylated heat- and acid-stable protein regulated by insulin 1
Description:
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Purification:The antibody is from purified?rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Concentration:1mg/ml
Buffer form:Liquid
Storage buffer:Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ¡ãC.Stable for 12 months from date of receipt
Specificity:
Phospho-4E-BP1 (Thr36) Antibody detects endogenous levels of 4E-BP1 only when phosphorylated at Threonine 36.
Storage conditions:Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Product specifications
Product specifications
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