Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Purification:affinity purification.
Concentration:1mg/ml
Buffer form:Liquid
Storage buffer:PBS, pH 7.4,50% glycerol.
Specificity:
Acetyl-Histone H3 (Lys18) Antibody detects endogenous levels of total Histone H3 protein only when acetylated at lysine18.