PurKine™ Protein L Purification system is effective for affinity purification of mammalian IgG that contain specific kappa light chains from serum, ascites fluid, cell culture supernantant and other antibody samples. Recombinant Protein L is chemically modified with a proprietary method to minimize nonspecific binding of proteins. Protein L is extremely useful for purification of VLk-containing monoclonal antibodies from culture supernatant because it does not bind bovine immunoglobilins, which are present in the media serum supplement. The portfolio allow optimization of process for maximum protein yield, stability and solubility. Tests also confirm that no decrease in performance occurs after at least five repeated uses. The PurKine™ Protein L Purification Resin is also available as prepacked spin column and kit formats.