Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000 ELISA 1:5000-20000.
Purification:The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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T-cell immunoglobulin and mucin domain-containing protein 3 (TIMD-3)
T-cell immunoglobulin mucin receptor 3 (TIM-3)
T-cell membrane protein 3
Buffer form:PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Storage conditions:Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Delivery conditions:Gel pack with blue ice.
Immunogen:Synthesized peptide derived from part region of human HAVR2 protein at amino acid sequence of 10-90
The protein encoded by HAVCR2 belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.