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Publication
Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
May/17/2020
Abstract
Cerebral Palsy (CP) is a complex neurological disorder, characterized by congenital motor disability associated with behaviour, perception and cognition disorders. The sensorimotor impairments represent the main hallmark of the disease, significantly impacting the quality of life. So far, few studies have investigated motor learning abilities in CP and their association with the plastic reorganization of the motor system remains largely unknown. The present proof-of-principle study explored explicit motor sequence learning in children with unilateral CP and different patterns of motor system reorganization (bilateral, ipsilateral, contralateral). Children with unilateral CP, and a group of age-matched typically developing (TD) children, underwent a sequential finger tapping task, performed with the affected hand by children with CP and with the non-dominant hand by TD children. The pattern of corticospinal tract projections in hemiparetic patients was assessed by single-pulse Transcranial Magnetic Stimulation (TMS). Results showed the presence of finger dexterity impairments in children with unilateral CP presenting with a bilateral or an ipsilateral control of the affected (trained) hand, as compared to TD children. Conversely, motor sequence learning was impaired in unilateral CP with ipsilateral or contralateral corticospinal reorganization, but not in the case of a bilateral control of the paretic hand. These preliminary findings, although referred to small clinical samples, suggest that unilateral control of the paretic upper-limb, from the ipsilateral or the contralateral motor cortex, may not be sufficient to develop typical motor learning with the affected hand, which seems to require a bilateral representation in the motor cortex. This evidence has potential implications for fine motor skills rehabilitation in CP.
Publication
Journal: International orthodontics
May/17/2020
Abstract
The objective of this study was to evaluate the effect of temperature variation on surface microhardness and resistance to flexion of different materials used for making a temporary dental disocclusion.One hundred specimens were made of the following materials (n=20): glass ionomer cement (GIC); compomer (CP); composite resin (CR); Blue colour resin composite for temporary dental disocclusion (BTDD); ultraviolet colour resin composite for temporary dental disocclusion (UVTDD). They were stored in distilled water for 24hours and, subsequently, half of the specimens in each group were subjected to thermal cycling (n=10). All samples were subjected to the microhardness test (HMV-2000) and the flexural strength analysis (INSTRON). The data were submitted to parametric statistical analysis (ANOVA) and Tukey's complementary test with a significance level of 5%. In the mechanical tests, all materials except the GIC showed a statistically significant difference between the groups subjected to thermal cycling and not submitted, and thermal cycling (P<0.05) was responsible for the reduction of the values found, except for GIC.In the mechanical tests, all materials except the GIC showed a statistically significant difference between the groups subjected to thermal cycling and not submitted, and thermal cycling (P<0.05) was responsible for the reduction of the values found, except for GIC. For microhardness, the highest average was found for BTDD and UVTDD (P≤0.05). As for the resistance, the flexion was found that in the groups not submitted to thermal cycling there was no statistically significant difference for all materials, except for GIC, for the groups with thermal cycling the materials BTDD and UVTDD showed a statistically significant difference from GIC, however, they did not differ statistically from the CP and CR groups.BTDD and UVTDD presented higher average results of surface microhardness and, in the resistance test, the flexion of these materials behaved similarly to the CP and the CR studied. The temperature variation has an effect on the properties of these materials.
Publication
Journal: The Annals of thoracic surgery
May/17/2020
Abstract
The Covid-19 pandemic has created unprecedented disruption in health care delivery around the world. In an effort to prevent hospital-acquired Covid-19 infections, most hospitals have severely curtailed elective surgery, performing only surgeries if the patient's survival or permanent function would be compromised by a delay in surgery. As hospitals emerge from the pandemic, it will be necessary to progressively increase surgical activity at a time when hospitals continue to care for Covid-19 patients. In an attempt to mitigate the risk of nosocomial infection, we have created a patient care pathway designed to minimize risk of exposure of patients coming in to the hospital for scheduled procedures. The "Covid-minimal surgery pathway" is a predetermined patient flow, that dictates the locations, personnel and materials that come in contact with our cancer surgery population, designed to minimize risk for virus transmission. We outline the approach that allowed a large academic medical center to create a Covid-minimal cancer surgery pathway within 7 days of initiating discussions. Although the pathway represents a combination of recommended practices, there is not data to support its efficacy. We share the pathway concept and our experience so that others wishing to similarly align staff and resources towards the protection of patients, may have an easier time navigating the process.
Publication
Journal: Journal of autoimmunity
May/17/2020
Abstract
To assess the incidence rate and risk of ankylosing spondylitis (AS) in patients with previous human papillomavirus (HPV) infection compared with those without HPV infection.All patients with HPV infection (n = 66,314) in the NHIRD (2003-2013) were individually matched with up to four control subjects without HPV infection by age and sex (n = 265,256). All of the patients were tracked until an AS event was noted. Chi-square test was used to analyze the distribution of sociodemographic characteristics in the HPV cohort and non-HPV cohort. Cox proportional hazards regression was used to calculate the HRs for the development of AS, adjusting for age, sex, urbanization, length of hospital stay, medications, and comorbidities adjustment. The Kaplan-Meier method was used to plot the cumulative incidence curves.The HPV cohort had a 1.329 (95% C.I. = 1.138-1.552) times higher risk of AS than that of the non-HPV cohort after adjusting for sex, age, urbanization, length of hospital stay, comorbidities, and medications. Additionally, we applied propensity score weighting to reconfirm the accuracy of our analysis, and the results showed a 1.348 (95% C.I. = 1.153-1.575) times greater risk of AS in the HPV cohort compared with the non-HPV cohort. The cumulative incidence curves plotted by the Kaplan-Meier method revealed that after 120 follow-up months, the HPV cohort displayed a higher cumulative incidence of AS than that of the non-HPV cohort. (Log-rank test p < 0.0001).Patients with HPV infection had a higher risk of developing AS compared with non-HPV patients.
Publication
Journal: Archives of biochemistry and biophysics
May/17/2020
Abstract
Increasing evidence indicates that aberrantly expressed microRNAs play a role in tumorigenesis and progression of gastric cancer. Recently, a novel cancer-related microRNA, miR-621, was found to be involved in cancer pathogenesis. However, the precise molecular mechanisms underlying the oncogenic activity of miR-621 remain unclear and require further investigation. In the current study, we demonstrate that miR-621 expression is downregulated in gastric cancer tissues and cell lines, and its reduction is associated with malignant clinical features including tumor size, lymph node metastasis, tumor-node-metastasis stage and poor prognosis. Functional studies involving gain- and loss-of-function experiments revealed that miR-621 represses cell viability, colony formation, cell cycle progression and proliferation in vitro, and miR-621 overexpression inhibited tumor growth in a gastric cancer xenograft model. SYF2 was identified as a direct target gene of miR-621 in gastric cancer. MiR-621 directly interacts with the SYF2 3'-UTR and post-transcriptionally repressed SYF2 expression in gastric cancer cells. SYF2 was significantly overexpressed in gastric cancer tissues and negatively correlated with miR-621 expression. Moreover, inhibition of SYF2 expression reversed the effects of miR-621 loss in gastric cancer cells. SYF2 overexpression was similar to that induced by miR-621 loss in gastric cancer. Taken together, these studies suggest that miR-621 may be a viable therapeutic target in gastric cancer.
Publication
Journal: Biochemical pharmacology
May/17/2020
Abstract
Pre-mRNA splicing is the removal of introns and ligation of exons to form mature mRNAs, and it provides a critical mechanism by which eukaryotic cells can regulate their gene expression. Strikingly, more than 90% of protein-encoding transcripts are alternatively spliced, through exon inclusion/skipping, differential use of 5' or 3' alternative splice sites, intron retention or selection of an alternative promoter, thereby drastically increasing protein diversity. Splicing is altered in various pathological conditions, including cancers. In the last decade, high-throughput transcriptomic analyses have identified thousands of splice variants in cancers, which can distinguish between tumoral and normal tissues as well as identify tumor types, subtypes and clinical stages. These abnormal or aberrantly expressed splice variants, found in all cancer hallmarks, can result from mutations in splice sites, deregulated expression or even somatic mutations of components of the spliceosome machinery. Therefore, and based on these recent observations, a new anti-cancer strategy of targeting the spliceosome machinery with small molecules has emerged; however, the potential for these therapies is still a matter of great debate. Notably, more preclinical studies are needed to clarify which splicing patterns are mainly affected by these compounds, which cancer patients could be the most eligible for these treatments and whether using these spliceosome inhibitors alone or in combination with chemotherapies or targeted therapies would provide better therapeutic benefits. In this commentary, I will discuss all of these aspects.
Publication
Journal: Biochimica et biophysica acta. Biomembranes
May/17/2020
Abstract
Lipidic bicelles have been widely used for the analysis of integral membrane proteins where their spontaneous alignment in an magnetic field has been exploited for oriented sample solid-state NMR studies. Many of their physical properties however make them well suited to the analysis of membrane proteins by circular dichroism (CD) and synchrotron radiation circular dichroism (SRCD). In this paper we have identified bicelle compositions that permit comparable studies of integral membrane proteins by solid-state NMR, CD, and SRCD; complementary methods that can provide insights into protein structure and the interactions with drugs and other small molecules. Furthermore we have been able to identify bicelle compositions that allow the magnetic alignment of the bicelles at fields routinely available in magnetic CD instruments. This potentially provides a route to the preparation of samples for oriented CD that mitigates many of the issues associated with the preparation of mechanically aligned samples, although we demonstrate that the dynamics present within the system can complicate the analysis of such spectra.
Publication
Journal: Progress in cardiovascular diseases
May/17/2020
Abstract
Natural disasters are devastating to not only our physical property but also to our health. There have been several studies over the last few decades that have correlated different types of natural disasters with acute myocardial infarctions (AMIs). Since the early 1930's singular meteorological events have been reported to have some association and effect on cardiovascular (CV) mortality and morbidity. Multiple natural disasters regardless of location have repeatedly reported a significant increase in the incidence of acute coronary syndromes (ACS). Each event was associated with similar mechanisms, which increase the overall CV mortality. The most prominent of those being neurohormonal activation, total scarcity of supplies and access to health care, poverty, stress, increased incidence of smoking and drug abuse. Increased incidence of associated infections added to the burden of ACS. We know natural disasters are inevitable; however, disaster preparedness is surely a reliable way to help curb their devastating effects on human life. In this manuscript, the authors present many forms of natural disasters and their association with acute myocardial infarction (AMI).
Publication
Journal: Behavioural processes
May/17/2020
Abstract
Humans have generally been considered risk averse for gains. Yet, growing evidence shows that risk preferences may change across reward currencies and depend on the type of tasks used to measure them. Here, we examined how context affects human risk preferences to shed light on the psychological mechanisms underlying human decision-making under risk. Participants were presented with a descriptive risky choice task involving repeated choices between real options and they were provided with trial-by-trial feedback. We manipulated the type of reward and, for the first time, the format of the choice stimuli. Options were either 2D computer-based images or concrete 3D objects, and participants received food or money as reward. First, we found that participants were more risk-seeking for food compared to money, suggesting that people treat money differently from consumable rewards. Second, we found that people were more risk-seeking when they made choices between concrete 3D objects than between 2D computer-based images. Our results strengthened the evidence that human choice patterns may change depending on the context and, for the first time, showed that the format of the choice stimuli does affect risk preferences, an important consideration for future research.
Publication
Journal: Journal of sport and health science
May/17/2020
Related with
Publication
Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
May/17/2020
Abstract
The aim of this study was to identify prognostic factors of overall survival in patients with FIGO stage IIIc or IVa ovarian cancer (OC) treated by neo-adjuvant chemotherapy (NAC) followed by interval debulking surgery.Data from 483 patients with ovarian cancer were retrospectively collected, from January 1, 2000 to December 31, 2016, from the FRANCOGYN database, regrouping data from 11 centers specialized in ovarian cancer treatment. Median overall survival was determined using the Kaplan-Meier method. Univariate and multivariate analysis were performed to define prognostic factors of overall survival.The median overall survival was 52 after a median follow up of 30 months. After univariate analysis, factors significantly associated with decreased overall survival were; no pelvic and/or para-aortic lymphadenectomy (p = 0.002), residual disease (CC1/CC2/CC3) after surgery (p < 0.001), positive cytology after NAC (p < 0.001), omental disease after NAC (p = 0.002), no pathologic complete response (pCR) (p = 0.002). In multivariate analysis, factors significantly associated with decreased overall survival were; residual disease after surgery (HR = 1.93; CI95% (1.16-3.21), p = 0.01) and positive cytology after NAC (HR = 1.59; CI95% (1.01-2.55), p = 0.05). Patients with no residual disease after surgery had a median overall survival of 64 months versus 35 months for patients with residual disease. Patients with negative cytology after NAC had a median overall survival of 71 months versus 43 months for patients with positive cytology after NAC.In this first and largest French based retrospective study, complete cytoreductive surgery in ovarian cancer remains the main prognostic factor of overall survival.
Publication
Journal: Revue d'epidemiologie et de sante publique
May/17/2020
Abstract
A high level of physical fitness is of major importance for cardiovascular health in children and adolescents. The main objective of this study was to describe the evolution of physical fitness levels among children in northern France. The secondary objective was to situate the physical fitness of these children with regard to preexisting French standards, assessing their condition at two time points over 3 years.The study presents a longitudinal design, with data collection when the children were 8 then 11 years old. All in all, 516 children (254 boys) aged 7.7±0.4 years (in 2010) and 10.9±0.4 years (in 2013) participated in the 3-year study. Cardiorespiratory endurance, muscular strength, speed and agility were assessed. For each physical fitness measurement, the condition of each child was evaluated (in terms of percentiles) in 2010 and then in 2013 in comparison with national standards. The 2010 and 2013 percentiles were then compared using the Wilcoxon signed-rank test.Between 2010 and 2013, muscular strength, agility and cardiorespiratory endurance decreased in both sexes (P<0.01). A significant decrease in all aspects of physical fitness was found in children of normal weight (P<0.05). Among children of normal weight in 2010 who had, by 2013, become overweight or obese, a significant decrease was noted in cardiorespiratory fitness and coordination/agility test scores (P<0.05). Among children who were overweight in 2010 but of normal weight in 2013, only the coordination/agility test performances decreased significantly (P<0.05). As for those who were overweight or obese in 2010 and whose weight status had not changed in 2013, all aspects of their physical fitness levels had significantly decreased (P<0.05).Our results indicate that the physical fitness of French youth in the Hauts-de-France region decreased significantly between childhood and early adolescence. They underline the importance of introducing and/or developing a health promotion curriculum in French schools in view of improving the overall health and physical condition of preteens and teens.
Publication
Journal: Brazilian journal of otorhinolaryngology
May/17/2020
Abstract
Endoscopic transnasal access to the skull base, both for treatment and reconstruction, can cause olfactory morbidity. Knowing the main consequences of this intervention is essential to have objective criteria for decision-making regarding the appropriate surgical technique.The aim of this study is to determine the impact on olfactory function of the endonasal endoscopic access to the skull base with the creation of the nasoseptal flap.

METHODS
A prospective research was carried out in which 22 patients who underwent endoscopic transnasal surgery at the skull base, with the creation of a nasoseptal flap. The Connecticut Chemosensory Clinical Research Center test was applied before and at the 1st, 3rd and 6th postoperative months.

RESULTS
The results showed that only in the first month of follow-up the mean patient classification was statistically worse than at the other evaluation moments (p<0.05), but there was no mean difference in the Connecticut score classification between the other moments (p>0.05); that is, patients showed worsening in the 1st month and returned to the preoperative mean after the 3rd month of follow-up.

CONCLUSION
The present study showed that the postoperative decrease in olfaction is transient, since the patient's sense of smell returns to pre-surgical values in the 3rd postoperative month.

Publication
Journal: Revue d'epidemiologie et de sante publique
May/17/2020
Abstract
Colorectal cancer is the third most common cancer and the second most deadly in France. A Cochrane meta-analysis has confirmed the benefits of colorectal cancer screening. A nationwide colorectal screening program was set up in France in 2009 for medium-risk, asymptomatic people aged 50 to 74 years. It has been based, since 2015, on the Fecal Immunochemical Test. The participation rate for 2016-2017 was 34%, which is lower than the European objectives. The objective of this study was to evaluate the impact of the program at the current participation rate and at rates of 45% and 65%.The epidemiological impact of the program was estimated from the results of an individual simulation model adapted from the Microsimulation Screening Analysis Colon model, calibrated and transposed to the French context. An initial analysis was conducted to estimate the individual impact of screening and a second for the entire eligible population, at various participation rates.The test is associated with a lifetime reduction in the risk of colorectal cancer of 24% for men and 21% for women, and a reduction in the risk of death from colorectal cancer of 51% and 43% respectively. At the current level of participation, the program reduces incidence by 5% and mortality by 14% compared to no organized screening. The impact would be reduced by an additional 3% and 8% for participation rates of 45% and 65% respectively. Similarly, mortality would decrease by an additional 8% and 22%.These results confirm that in a population at medium risk for colorectal cancer, the organised programme is an effective strategy for reducing its incidence. They also confirm that the achievement of European objectives remains a key issue for improving the effectiveness of organized screening. An evolution of immunological test delivery modalities could help to achieve these participation objectives.
Publication
Journal: Disability and health journal
May/17/2020
Abstract
Vision impairment (VI) is a significant risk factor for depression among older adults. The stigma attached to VI, which has multidimensional aspects consisting of ageism and ableism, may constitute a major impediment to accepting one's VI and engaging in help-seeking behaviors, which could have led to suicide prevention.This study aims to investigate the relative strength of association for VI on suicidal ideation among a nationally representative sample of older adults.The study sample was composed of 10,635 adults aged 65 years and over, drawn from the 2015-2017 National Survey on Drug Use and Health. Respondents were asked if they had serious thoughts about suicide in the past year.Of the total sample, 6.85% reported VI (n = 729), defined as being blind or having serious difficulty seeing, even when wearing glasses. In comparison to those without VI, older adults with VI were more likely to report impoverished sociodemographic status and poor health conditions. After adjusting for a comprehensive set of covariates, multivariate logistic regression analyses revealed that older adults with VI were more likely to report suicidal ideation, compared to their counterparts without VI (OR = 3.12, 95% CI [1.24, 7.85]. p < 0. 05). Of the covariates, major depressive episodes presented the strongest positive association with suicidal ideation (OR = 14.11, 95% CI [8.93, 22.29], p < 0. 05).This study contributes to the scant body of literature by identifying the relative strength of association between VI and suicide in a nationally representative sample.
Publication
Journal: Chest
May/17/2020
Publication
Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
May/17/2020
Publication
Journal: Clinical genitourinary cancer
May/17/2020
Publication
Journal: Brazilian journal of otorhinolaryngology
May/17/2020
Publication
Journal: The ocular surface
May/17/2020
Abstract
High resolution visualization of the ocular surface and intact eyeball is critical and essential for our understanding and treatment of eye diseases. This study is to achieve this goal using advanced tissue clearing and three-dimensional (3D) imaging technologies.Wild type and fluorescently labeled transgenic mice of Prox-1-GFP (green fluorescent protein) or Thy1-YFP (yellow fluorescent protein) were used in the study. Eyeballs were harvested from normal or a disease model of corneal inflammation. Samples were infused with hydrogel monomers and heated for polymerization. Lipids were removed by electrophoresis. The transparent tissue-hydrogel hybrids of the anterior segments or intact eyeballs with immunolabeling or endogenous fluorescence were imaged by an advanced light sheet fluorescent microscope. High resolution 3D images and videos were captured for a wide array of structures and cell types.Optical transparency was achieved from intact eyeballs of both normal and diseased conditions. A variety of important structures and cell types, such as blood and lymphatic vessels, Schlemm's canal, nerves and endothelial cells, were detected with their natural morphology, location and organizational network.This study provides the first comprehensive and 3D high resolution imaging of the intact eyeball using tissue clearing and advanced light sheet microscopy. Given that the eye is the window of the body, we anticipate this advanced technology will facilitate diverse applications in biomedical research inside and outside the eye.
Publication
Journal: Annales de chirurgie plastique et esthetique
May/17/2020
Abstract
Ambulatory or outpatient surgery is defined as surgery that does not require an overnight hospital stay. It offers patients both convenience and reduced costs. With the increased use of bariatric surgery, Extended L-shaped Lipo-brachioplasty is now frequently requested as a follow-up procedure. Although numerous studies have focused on its technique and outcomes, none have evaluated its acceptability as an outpatient procedure. This was the aim of this prospective study.This study was performed between January 2016 and September 2019. All patients undergoing extended L-shaped Lipo-brachioplasty during that period were included and divided into two groups, according to the type of hospitalization. For both groups, we recorded the demographics, medical and surgical data, as well as any postoperative complications. In the outpatient group, we also recorded discharge failures at day 0.75 patients were included in the study (40 outpatients, 35 hospitalizations). There were no significant differences between the two groups in terms of demographics, surgical data, or the incidence of complications. In the outpatient group, three patients could not be discharged the evening of the procedure and had to stay overnight. No readmissions or major complications were reported in this group.Our prospective study shows that outpatient Extended L-shaped Lipo-brachioplasty safely provides the same outcomes as those performed during traditional hospitalization. We believe that for eligible patients, it should routinely be performed as an outpatient procedure.
Publication
Journal: Revista espanola de anestesiologia y reanimacion
May/17/2020
Abstract
Postoperative management of patients with the congenital growth disorder Beckwith-Wiedemann syndrome (BWS) can be complicated. The main clinical manifestations of the syndrome are macroglossia - which may hamper airway management -, prematurity, hemihypertrophy, omphalocele, embryonal tumours and episodes of neonatal hypoglycaemia.Our main objective is to describe the perioperative management and potential anaesthetic complications in paediatric patients with BWS undergoing glossectomy.Case report and literature review.

RESULTS
We describe the case of an 11-month-old patient diagnosed with BWS who underwent reduction glossoplasty. We performed a comprehensive preoperative evaluation, taking into account potential anaesthetic complications derived from both macroglossia and prematurity, and the risk of hypoglycaemia. The procedure was performed under general anaesthesia. Intubation - performed according to difficult airway management algorithms - was uneventful and the patient was successfully extubated in the operating room. The patient remained stable during the postoperative period, with good respiratory dynamics, SatO2>96% and good glycaemic control. Oral intake was started 4hours after surgery, and she was discharged to the ward at 24hours.

BWS patients require a multimodal approach that includes detailed preoperative planning and knowledge of potential airway-related and systemic complications.
Publication
Journal: Best practice & research. Clinical rheumatology
May/17/2020
Abstract
Rheumatic and Musculoskeletal Diseases (RMDs) are chronic conditions that affect a substantial number of people. RMDs are significantly related to co-morbidity. Therefore, focusing on prevention in RMDs is of importance to promote and maintain health. Prevention includes primary-, secondary-, tertiary-, and clinical prevention. Primary prevention aims to prevent the onset of disease before the disease process begins, secondary prevention includes detecting and reducing disease and risk factors at the earliest possible point, and tertiary prevention aims to limit the influence of a recognized or verified disease and to address or reduce further development or worsening of the disease, including physical and psychosocial disability. Clinical prevention attempts to integrate prevention into the disease management to limit disease progression and prevent complications and relapse. This chapter will focus on the evidence for prevention and highlight how innovations and trends can contribute by using digital technologies as an example.
Publication
Journal: Social science & medicine (1982)
May/17/2020
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