4-Aminopyridine
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(3830)
Drug or chemical
4-Aminopyridine
Description
One of the POTASSIUM CHANNEL BLOCKERS with secondary effect on calcium currents which is used mainly as a research tool and to characterize channel subtypes.
Related with
3831
1
95
Pubmed
Action potential repolarization and a fast after-hyperpolarization in rat hippocampal pyramidal cells.
Journal: The Journal of physiology
November/16/1987
Matched by
4-Aminopyridine
Authors
Related with
205
64
10
2
2
2
1
1
Pubmed
Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.
Journal: The EMBO journal
December/28/1989
Matched by
4-Aminopyridine
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Related with
195
46
4
4
3
7
1
9
Pubmed
GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells.
Journal: Neuron
December/6/2005
Matched by
4-Aminopyridine
Authors
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Related with
186
26
3
3
3
5
Pubmed
Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome.
Journal: Circulation
December/10/1998
Matched by
4-Aminopyridine
Authors
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Related with
153
3
3
2
1
4
1
2
Pubmed
One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction.
Journal: Nature neuroscience
October/11/1999
Matched by
4-Aminopyridine
Authors
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Related with
151
30
2
9
2
2
1
1
2
Pubmed
Hippocampal astrocytes in situ respond to glutamate released from synaptic terminals.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience
December/12/1996
Matched by
4-Aminopyridine
Authors
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Related with
143
5
2
1
5
1
2
Pubmed
Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy.
Journal: Neuron
October/18/2007
Matched by
4-Aminopyridine
Authors
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Related with
138
5
3
3
4
1
3
Pubmed
Acquired dendritic channelopathy in temporal lobe epilepsy.
Journal: Science (New York, N.Y.)
August/8/2004
Matched by
4-Aminopyridine
Authors
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Related with
137
11
1
3
3
3
6
Pubmed
Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience
January/22/2002
Matched by
4-Aminopyridine
Authors
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Related with
125
1
9
3
3
3
1
11
Pubmed
Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus.
Journal: Nature neuroscience
July/1/2004
Matched by
4-Aminopyridine
Authors
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Related with
118
21
3
2
2
1
5
Pubmed
Comparison of potassium currents in rabbit atrial and ventricular cells.
Journal: The Journal of physiology
September/26/1989
Matched by
4-Aminopyridine
Authors
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Related with
117
56
4
2
3
3
1
2
Pubmed
Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells.
Journal: Circulation research
January/1/1992
Matched by
4-Aminopyridine
Authors
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Related with
117
10
1
3
4
2
1
8
Pubmed
Properties of adenosine-triphosphate-regulated potassium channels in guinea-pig ventricular cells.
Journal: The Journal of physiology
September/10/1985
Matched by
4-Aminopyridine
Authors
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Related with
112
44
9
2
4
3
3
Pubmed
Sustained depolarization-induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents.
Journal: Circulation research
December/21/1993
Matched by
4-Aminopyridine
Authors
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Related with
112
3
1
2
3
1
3
Pubmed
Distinct short-term plasticity at two excitatory synapses in the hippocampus.
Journal: Proceedings of the National Academy of Sciences of the United States of America
December/29/1996
Matched by
4-Aminopyridine
Authors
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Related with
109
22
9
2
4
5
1
4
Pubmed
Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro.
Journal: Progress in neurobiology
March/4/2003
Matched by
4-Aminopyridine
Authors
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Related with
107
6
3
2
3
3
1
8
Pubmed
Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model.
Journal: Circulation
June/14/2005
Matched by
4-Aminopyridine
Authors
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Related with
105
52
15
2
3
5
2
Pubmed
Unique roles of SK and Kv4.2 potassium channels in dendritic integration.
Journal: Neuron
December/14/2004
Matched by
4-Aminopyridine
Authors
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Related with
103
7
2
1
3
1
7
Pubmed
Expression mechanisms underlying NMDA receptor-dependent long-term potentiation.
Journal: Annals of the New York Academy of Sciences
August/11/1999
Matched by
4-Aminopyridine
Authors
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Related with
102
9
1
2
2
1
2
Pubmed
Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience
March/30/2006
Matched by
4-Aminopyridine
Authors
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Related with
99
13
4
5
4
2
Pubmed
Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience
June/15/1999
Matched by
4-Aminopyridine
Authors
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Related with
96
3
2
3
2
4
1
2
Pubmed
Developmental changes in the expression of potassium currents of embryonic, neonatal and mature mouse inner hair cells.
Journal: The Journal of physiology
December/3/2003
Matched by
4-Aminopyridine
Authors
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Related with
95
33
9
3
3
2
1
4
Pubmed
Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial.
Journal: Lancet (London, England)
March/11/2009
Matched by
4-Aminopyridine
Authors
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Related with
95
3
1
1
1
1
6
9
Pubmed
Functional and molecular differences between voltage-gated K+ channels of fast-spiking interneurons and pyramidal neurons of rat hippocampus.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience
October/22/1998
Matched by
4-Aminopyridine
Authors
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Related with
94
11
3
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