Natalizumab
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Pubmeds
(1224)
Drug or chemical
Natalizumab
Description
A humanized monoclonal immunoglobulin G4 antibody to human INTEGRIN ALPHA4 that binds to the alpha4 subunit of INTEGRIN ALPHA4BETA1 and integrin alpha4beta7. It is used as an IMMUNOLOGIC FACTOR in the treatment of RELAPSING-REMITTING MULTIPLE SCLEROSIS and CROHN'S DISEASE.
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A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis.
Journal: The New England journal of medicine
March/6/2006
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Progressive multifocal leukoencephalopathy in a patient treated with natalizumab.
Journal: The New England journal of medicine
August/1/2005
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Natalizumab plus interferon beta-1a for relapsing multiple sclerosis.
Journal: The New England journal of medicine
March/6/2006
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Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis.
Journal: The New England journal of medicine
August/1/2005
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265
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Risk of natalizumab-associated progressive multifocal leukoencephalopathy.
Journal: The New England journal of medicine
May/23/2012
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Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease.
Journal: The New England journal of medicine
August/1/2005
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A controlled trial of natalizumab for relapsing multiple sclerosis.
Journal: The New England journal of medicine
January/5/2003
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Natalizumab
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205
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Natalizumab induction and maintenance therapy for Crohn's disease.
Journal: The New England journal of medicine
November/7/2005
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Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy.
Journal: The New England journal of medicine
March/6/2006
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Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases.
Journal: The Lancet. Neurology
April/11/2010
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Natalizumab for active Crohn's disease.
Journal: The New England journal of medicine
January/5/2003
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Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project.
Journal: The Lancet. Oncology
September/8/2009
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Immune surveillance in multiple sclerosis patients treated with natalizumab.
Journal: Annals of neurology
June/13/2006
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Natalizumab for the treatment of active Crohn's disease: results of the ENCORE Trial.
Journal: Gastroenterology
June/25/2007
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Anti-JC virus antibodies: implications for PML risk stratification.
Journal: Annals of neurology
September/23/2010
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Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: a retrospective analysis of the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) study.
Journal: The Lancet. Neurology
March/25/2009
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The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response?
Journal: The American journal of gastroenterology
April/19/2011
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Efficacy of biological therapies in inflammatory bowel disease: systematic review and meta-analysis.
Journal: The American journal of gastroenterology
June/5/2011
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Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale.
Journal: Neurology
January/19/2006
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Anti-JC virus antibody levels in serum or plasma further define risk of natalizumab-associated progressive multifocal leukoencephalopathy.
Journal: Annals of neurology
January/25/2015
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Blocking adhesion molecules as therapy for multiple sclerosis: natalizumab.
Journal: Nature reviews. Drug discovery
July/4/2005
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Natalizumab for multiple sclerosis.
Journal: The New England journal of medicine
June/28/2007
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Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis.
Journal: Archives of neurology
November/20/2006
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Asymptomatic reactivation of JC virus in patients treated with natalizumab.
Journal: The New England journal of medicine
September/20/2009
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