Lei Zhang
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Pubmed
Journal: Bioorganic & medicinal chemistry letters
April/23/2014
Abstract
Potent, reversible inhibition of the cytochrome P450 CYP2C9 isoform was observed in a series of urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. This unwanted property was successfully removed from the described inhibitors through a combination of structure-based design and medicinal chemistry activities. An optimized compound which did not inhibit CYP2C9 exhibited potent anti-NAMPT activity (17; BC NAMPT IC50=3 nM; A2780 antiproliferative IC50=70 nM), good mouse PK properties, and was efficacious in an A2780 mouse xenograft model. The crystal structure of this compound in complex with the NAMPT protein is also described.
Pubmed
Journal: Pesticide biochemistry and physiology
October/12/2016
Abstract
Emamectin benzoate (EMB), an important macrocyclic lactone insecticide that belongs to the avermectin family and possesses excellent potency in controlling pests, is non-carcinogenic and non-mutagenic conducted in rats and mice, but EMB-induced cytotoxicity and genotoxicity in arthropod insect have been seldom reported yet. In the present paper, we quantified the cytotoxicity of EMB through the detections on cell viability, DNA damage, and cell apoptosis in Spodoptera frugiperda Sf-9 cells in vitro. The results showed that EMB caused a concentration- and time-dependent reduction on the viability of Sf-9 cells, and the median inhibitory concentrations (IC50) were 3.34μM at 72h of exposure. The dual acridine orange/ethidium bromide staining showed that exposure to EMB induced a significant time- and concentration-dependent increase on cell apoptosis. The alkaline comet assay revealed that EMB induced significant increases on single-strand DNA breaks, and the percentage of γH2AX-positive cells represented a time- and concentration-dependent formation of DNA double-strand breaks in Sf-9 cells. Interestingly, the similar cytotoxic actions of EMB also went for the human cancerous HeLa cells as a control cell group. Data demonstrated the potential cytotoxic effect of EMB on Sf-9 cells that was significantly greater than the effect of hydrogen peroxide at the same concentrations.
Pubmed
Journal: The Science of the total environment
January/8/2015
Abstract
Nonferrous metal smelting is an important atmospheric mercury (Hg) emission source that has significant local and global impacts. To quantify the impact of Hg emission from non-ferrous metal smelter on the surrounding soil, an integrated model parameterizing the processes of smelter emission, air dispersion, atmospheric deposition and Hg accumulation in soil was developed. The concentrations of gaseous elemental Hg (GEM) around the smelter and the spatial distribution of Hg in the surrounding soil were measured and compared with the model results. Atmospheric deposition of Hg emitted from the smelter was identified as the main source of Hg accumulation in the surrounding soil. From 1960 to 2011, the smelter emitted approximately 105 t of Hg into the atmosphere, of which 15 t deposited locally and resulted in an increase of Hg concentration in soil from 0.12 to 1.77 mg kg(-1). A detailed examination of wind rose and model data suggested that the area within 1.0-1.5 km northwest and southeast of the smelter was most severely impacted. It was estimated that the smelter operation from 1969 to 1990, when large scale emission controls were not implemented, resulted in 6450 μg m(-2)yr(-1) of Hg net deposition and a model simulated increase of 0.40 mg kg(-1) of Hg accumulation in the soil. During the period from 1991 to 2011, atmospheric Hg emission from the smelter alone increased the average concentration in soil from 0.41 mg kg(-1) to 0.45 mg kg(-1). In the past 50 years, over 86% of Hg emitted from this smelter went into the global pool, indicating the importance of controlling Hg emissions from non-ferrous metal smelters.
Pubmed
Journal: Biofabrication
March/21/2016
Abstract
The densification of pore struts in bioceramic scaffolds is important for structure stability and strength reliability. An advantage of ceramic ink writing is the precise control over the microstructure and macroarchitecture. However, the use of organic binder in such ink writing process would heavily affect the densification of ceramic struts and sacrifice the mechanical strength of porous scaffolds after sintering. This study presents a low-melt-point bioactive glass (BG)-assisted sintering strategy to overcome the main limitations of direct ink writing (extrusion-based three-dimensional printing) and to produce high-strength calcium silicate (CSi) bioceramic scaffolds. The 1% BG-added CSi (CSi-BG1) scaffolds with rectangular pore morphology sintered at 1080 °C have a very small BG content, readily induce apatite formation, and show appreciable linear shrinkage (∼21%), which is consistent with the composite scaffolds with less or more BG contents sintered at either the same or a higher temperature. These CSi-BG1 scaffolds also possess a high elastic modulus (∼350 MPa) and appreciable compressive strength (∼48 MPa), and show significant strength enhancement after exposure to simulated body fluid-a performance markedly superior to those of pure CSi scaffolds. Particularly, the honeycomb-pore CSi-BG1 scaffolds show markedly higher compressive strength (∼88 MPa) than the scaffolds with rectangular, parallelogram, and Archimedean chord pore structures. It is suggested that this approach can potentially facilitate the translation of ceramic ink writing and BG-assisted sintering of bioceramic scaffold technologies to the in situ bone repair.
Pubmed
Journal: Canadian journal of microbiology
January/27/2015
Abstract
Modification of the anoxic-oxic (AO) process by inserting a sludge holding tank (SHT) into the sludge return line forms an anoxic-oxic-settling-anaerobic (A+OSA) process that can achieve a 48.98% sludge reduction rate. The 454 pyrosequencing method was used to obtain the microbial communities of the AO and A+OSA processes. Results showed that the microbial community structures of the 2 processes were different as a result of the SHT insertion. Bacteria assigned to the phyla Proteobacteria and Bacteroidetes commonly existed and dominated the microbial populations of the 2 processes. However, the relative abundance of these populations shifted in the presence of SHT. The relative abundance of Proteobacteria decreased during the A+OSA process. A specific comparison at the class level showed that Sphingobacteria was enriched in the A+OSA process. The result suggested that the fermentative bacteria Sphingobacteria may have key functions in reducing the sludge from the A+OSA process. Uncultured Nitrosomonadaceae gradually became the dominant ammonia-oxidizing bacteria, and the nitrite-oxidizing bacterium Nitrospira was enriched in the A+OSA process. Both occurrences were favorable for stabilized nitrogen removal. The known denitrifying species in the A+OSA process were similar to those in the AO process; however, their relative abundance also decreased.
Pubmed
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
January/7/2013
Abstract
OBJECTIVE
To analyze reasons for disapproval of registration application of new traditional Chinese medicines in recent years and discuss potential problems occurring in R&D and registration administration of new traditional Chinese medicines in China.
METHODS
All applications of new traditional Chinese medicines for registrations that had been disapproved by Center for Drug Evaluation of State Food Drug Administration from 2006 to 2008 were searched in data bank. Specific reasons for disapproval of each variety were inquired and sorted out. The statistics involved the proportion of each type (kind) disapproval reasons in all disapprovals in order to analyze which were the main reasons. The results were analyzed to find out potential problems occurring in R&D and registration administration of new traditional Chinese medicines in China.
RESULTS
There were totally 247 disapproved registration applications for new traditional Chinese medicines. Among them, there were 218 applications for clinical trials and 29 applications for launch in the market There were 9 categories (29 types) of reasons for the applications for clinical trials applications, mainly including such problems as R&D proposal, non-clinical effectiveness and non-clinical safety; while there were 5 categories (9 types) of reasons for the applications for launch in the market, with clinical effectiveness as the main reason.
CONCLUSIONS
There were many kinds of reasons for the disapproval registration applications of new traditional Chinese medicines in recent years in China, mainly including such problems as effectiveness, safety and proposal basis. This reflects problems occurring in R&D and registration administration of new traditional Chinese medicines in China to some extent.
Pubmed
Journal: Small (Weinheim an der Bergstrasse, Germany)
May/17/2017
Abstract
SnO2 suffers from fast capacity fading in lithium-ion batteries due to large volume expansion as well as unstable solid electrolyte interphase. Herein, the design and synthesis of phosphorus bridging SnO2 and graphene through covalent bonding are demonstrated to achieve a robust structure. In this unique structure, the phosphorus is able to covalently "bridge" graphene and tin oxide nanocrystal through PC and SnOP bonding, respectively, and act as a buffer layer to keep the structure stable during charging-discharging. As a result, when applied as a lithium battery anode, SnO2 @P@GO shows very stable performance and retains 95% of 2nd capacity onward after 700 cycles. Such unique structural design opens up new avenues for the rational design of other high-capacity materials for lithium battery, and as a proof-of-concept, creates new opportunities in the synthesis of advanced functional materials for high-performance energy storage devices.
Pubmed
Journal: Talanta
December/10/2009
Abstract
A novel electrochemical sensor with capability of probing chiral amino acids with gold nanoparticle (n-Au) labels using bovine serum albumin (BSA) as a chiral selector and subsequent signal amplification step by silver enhancement is introduced. The assay relies on the stereoselectivity of BSA embedded in ultrathin gamma-alumina sol-gel film coated on the surface of the glassy carbon electrode (GCE). The recognition to the n-Au-labeled L- or D-amino acids for BSA-GCE could be monitored by the differential pulse voltammetry (DPV), while the DPV signal was greatly amplified by the anchored silver atoms on the n-Au, leading to a new way of quantitatively analysis of chiral amino acids electrochemically at sub-picomolar level. With L-tryptophan as the probe solute, the linear concentration range was from 1.33 x 10(-12) to 1 x 10(-9)mol L(-1) and detection limit was 5 x 10(-13)mol L(-1). For tryptophan enantiomers, the enantioselectivity coefficient 2.3 was obtained.
Pubmed
Journal: Zhonghua xin xue guan bing za zhi
December/14/2009
Abstract
OBJECTIVE
To evaluate the value of brain natriuretic peptide (BNP) in estimating risk stratification in patients with acute myocardial infarction (AMI) and to determine the relationship between BNP and adverse cardiac events after AMI.
METHODS
The 135 subjects were selected into the study, including 25 healthy subjects and 110 patients with a first AMI. The plasma concentrations of BNP were measured at two to four days after infarction in patients and healthy controls. Left ventricular function was evaluated by echocardiography with the parameters of left ventricular ejection function (LVEF) after 3 months. Patients were followed up at 12 months. The main outcome measures were heart failure, left remodeling, mortality and other adverse cardiac events at one year.
RESULTS
Plasma BNP concentrations in patients with AMI were much higher than those in the health control people (416.7 +/- 208.0 ng/L versus 61.8 +/- 34.1 ng/L, P < 0.01). The BNP count ranged from 5 to 2500 ng/L in AMI patients. There was no association between the BNP count and mortality rate. The development of new congestive heart failure (CHF) was associated with a higher BNP count (P = 0.02). The development of any of the clinical end points (death/CHF/shock) occurred more frequently in patients with a higher BNP count (13.8% for BNP count of < 100 ng/L, 39.1% for BNP count of 100 - 200 ng/L, 43.3% for BNP count of 200 - 400 ng/L, 46.4% for BNP count of > 400 ng/L; P = 0.019). Plasma BNP concentrations remained independently associated with the development of clinical end points in multivariable model that adjusted for potential confounding variables.
CONCLUSIONS
The results of the present study confirm that the elevated BNP count related to the risk stratification and prognosis in patients with AMI. Elevations in BNP count are associated with a higher incidence of new CHF and adverse clinical outcomes after AMI. It could serve as a strong predictor for the subsequent development of poor outcomes in AMI patients.
Pubmed
Journal: Antonie van Leeuwenhoek
August/18/2015
Abstract
A white-coloured bacterium, designated strain GTJR-20(T), was isolated from a stem of Phytolacca acinosa Roxb. collected from Taibai Mountain in Shaanxi Province, north-west China, and was subjected to a taxonomic study by using a polyphasic approach. The novel isolate was found to grow optimally at 28-30 °C, at pH 7.5-8.0 and in the absence of NaCl. Cells were observed to be Gram-stain positive, strictly aerobic, rod-shaped and non-motile. The predominant respiratory quinone was identified as MK-7(H4) and the major cellular fatty acids were identified as iso-C16:0 (35.8 %), C18:1 ω9c (17.7 %), C17:1 ω6c (11.0 %), C17:1 ω8c (7.8 %) and C18:3 ω6c (6, 9, 12) (7.2 %). The DNA G+C content was determined to be 71.6 mol %. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain GTJR-20(T) is a member of the genus Solirubrobacter and is closely related to Solirubrobacter phytolaccae GTGR-8(T) (16S rRNA gene sequence similarity, 98.4 %), Solirubrobacter soli KCTC 12628(T) (97.8 %), Solirubrobacter pauli KCTC 9974(T) (97.7 %) and Solirubrobacter ginsenosidimutans KCTC 19420(T) (97.6 %). No other recognized bacterial species showed more than 94.6 % 16S rRNA gene sequence similarity to the novel isolate. DNA-DNA relatedness values for strain GTJR-20(T) with respect to its closely related neighbours S. phytolaccae GTGR-8(T), S. soli KCTC 12628(T), S. pauli KCTC 9974(T) and S. ginsenosidimutans KCTC 19420(T) were 48.3 ± 8.6, 21.3 ± 5.2, 36.8 ± 6.2 and 36.0 ± 5.5 %, respectively. Based on the phenotypic, phylogenetic and genotypic data, strain GTJR-20(T) is considered to represent a novel species of the genus Solirubrobacter, for which the name Solirubrobacter taibaiensis sp. nov. is proposed. The type strain is GTJR-20(T) (=CCTCC AB 2013308(T) = KCTC 29222(T)).
Pubmed
Journal: Optics express
June/1/2009
Abstract
We designed and fabricated a four-channel reconfigurable optical add-drop multiplexer based on silicon photonic wire waveguide controlled through thermo-optic effect. The effective footprint of the device is about 1000 x 500 microm(2). The minimum insertion loss is about 10.7 dB and the tuning bandwidth about 17 nm. The average tuning power efficiency is about 6.187 mW/nm and the tuning speed about 24.4 kHz. The thermo-optic polarization-rotation effect is firstly reported in this paper.
Pubmed
Journal: Journal of environmental management
October/28/2018
Abstract
In this study, Eucalyptus sawdust was hydrothermally carbonized, and the resulting biochar was modified by a low concentration potassium hydroxide. The morphology and surface property was characterized by SEM-EDS, BET, FTIR and XPS techniques. A series of batch adsorption experiments were conducted to screen out the optimum conditions, and to investigate the isotherm, kinetics and thermodynamic behaviors. The results indicated that a high adsorption capacity of hexavalent chromium (qe 45.88 mg/g) was achieved by the combining of hydrothermal carbonization at 220 °C and 0.05 N potassium hydroxide modification, and a high biochar yield (47.61%) was obtained. The isotherm, kinetics and thermodynamic studies suggested that the spontaneously and endothermically chemical adsorption was the main mechanism, which was partially supported by BET, FTIR and XPS results. This finding suggested that the combination of hydrothermal carbonization and a subsequent low alkali modification was an effective method to prepare a high-performance adsorbent for hexavalent chromium removal.
Pubmed
Journal: Guang pu xue yu guang pu fen xi = Guang pu
August/5/2018
Abstract
A laboratory cement quality analysis apparatus based on laser-induced breakdown spectroscopy (LIBS) has been developed for rapid analysis of cement composition and ratio values. In this paper, the overall structure, the optical system, the sample preparation process, as well as the spectral data analysis methods are introduced. The calibration model is established with internal standard method. A comparison as to the measurement results between LIBS and X-ray fluorescence spectrometry (XRF) has been made and being analyzed. It shows that by using the LIBS apparatus, the mean absolute error of CaO, SiO2, Al2O3, and Fe2O3 in cement raw materials is 0.46%, 0.25%, 0.13%, and 0.05%, respectively, while the mean absolute error of the ratio value such as KH, SM, and IM in cement clinker is 0.02, 0.05, and 0.04, respectively. The generated cement plasmas are verified to be in the local thermal equilibrium (LTE) condition by calculating both the plasma temperature and the electron density.
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Pubmed
Journal: Journal of the American College of Surgeons
June/28/2015
Pubmed
Journal: Virus research
April/14/2015
Abstract
In 2013, the novel reassortant avian-origin influenza A (H7N9) virus was reported in China. Through enhanced surveillance, infection by the H7N9 virus in humans was first identified in Zhejiang Province. Real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) was used to confirm the infection. Embryonated chicken eggs were used for virus isolation from pharyngeal swabs taken from infected human patients. The H7N9 isolates were first identified by the hemagglutination test and electron microscopy, then used for whole genome sequencing. Bioinformatics software was used to construct the phylogenetic tree and for computing the mean rate of evolution of the HA gene in H7Nx and NA in HxN9. Two novel H7N9 avian influenza A viruses (A/Zhejiang/1/2013 and A/Zhejiang/2/2013) were isolated from the positive infection cases. Substitutions were found in both Zhejiang isolates and were identified as human-type viruses. All phylogenetic results indicated that the novel reassortant in H7N9 originated in viruses that infected birds. The sequencing and phylogenetic analysis of the whole genome revealed the mean rate of evolution of the HA gene in H7NX to be 5.74E-3 (95% Highest posterior density: 3.8218E-3 to 7.7873E-3) while the NA gene showed 2.243E-3 (4.378E-4 to 3.79E-3) substitutions per nucleotide site per year. The novel reassortant H7N9 virus was confirmed by molecular methods to have originated in poultry, with the mutations occurring during the spread of the H7N9 virus infection. Live poultry markets played an important role in whole H7N9 circulation.
Pubmed
Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment
October/30/2017
Abstract
An analytical method was established for the rapid detection of antibiotic growth promoters (AGPs) in bovine muscle, and bovine blood and bovine urine, using ultra high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). After the addition of an aqueous solution of EDTA-Na2, the pH of bovine urine samples was directly adjusted to 5.2 by acetic acid-ammonium acetate and purified by HLB solid-phase extraction cartridge; bovine muscle and bovine blood samples processing were extracted with acetonitrile (ACN) and ACNwater (90:10; v/v) without any purification step. The samples were then centrifuged, concentrated and analysed by UPLC-MS/MS on an ACQUITY UPLC® BEH C18 column using gradient elution. The developed method was validated and mean recovery percentages at three spiked levels were 74-119%, 76-115% and 76-119%, respectively, in bovine muscle, bovine blood, and bovine urine. The relative standard deviation (RSD) ranged from 1.0% to 14.7% in spiked bovine muscle, bovine blood and bovine urine. The limits of detection (LOD) of all analytes were in the ranges 0.11-3.82 µg kg-1, 0.10-2.49 µg kg-1 and 0.06-4.53 µg kg-1 in bovine muscle, bovine blood, and bovine urine, respectively. The method was sensitive, accurate and was applied to monitor real samples. To the best of our knowledge, this is first method available for simultaneous determination of several classes of APGs in bovine muscle, and bovine blood and bovine urine.
Pubmed
Journal: Langmuir : the ACS journal of surfaces and colloids
February/27/2017
Abstract
Hyper-cross-linked polynaphthalene nanoparticles (PNNs) capable of catalyzing the degradation of organic pollutants upon exposure to visible light have been developed. The nascent and metal-free PNNs with a porous structure, high specific surface area, and narrow bandgap are chemically and thermally stable in the catalytic system, which make it promising as a kind of excellent photocatalytic material compared to conventional photocatalysts. The photocatalytic activity of the as-obtained PNNs exhibits remarkable photocatalytic performance for the degradation of rhodamine B (RhB) and methyl blue (MB) under the irradiation of visible light. The easy preparation, high catalytic activity, and recyclability of the PNNs open new opportunities in the visible-light-promoted degradation of organic pollutants.
Pubmed
Journal: Water science and technology : a journal of the International Association on Water Pollution Research
February/27/2017
Abstract
Microbubble aeration is supposed to be highly efficient for oxygen supply in aerobic wastewater treatment. In the present study, the performance of a fixed-bed biofilm reactor microbubble-aerated using a Shirasu porous glass (SPG) membrane system was investigated when treating synthetic municipal wastewater. The biofilm formation on the carriers was enhanced with microbubble aeration due to the strong adhesion of microbubbles to the solid surface. The dissolved oxygen concentration, the removals of chemical oxygen demand (COD) and nitrogen, and the oxygen utilization efficiency were influenced by the organic loading rate at a certain oxygen supply capacity. The relatively optimal organic loading rate was determined as 0.82 kgCOD/(m(3)d) when the oxygen supply capacity was 0.93 kgO(2)/(m(3)d), where COD and ammonia removal efficiencies were 91.7% and 53.9%, respectively. The corresponding SPG membrane area-based COD removal capacity was 6.88 kgCOD/(m(2)d). The oxygen utilization efficiency of microbubble aeration was obviously higher compared to conventional bubble aeration. The simultaneous nitrification and denitrification occurred in the biofilm reactor and the total nitrogen removal efficiency of 50.4% was achieved under these conditions. In addition, the increase in air supply capacity of the SPG membrane system was suggested to improve its energy utilization efficiency.
Pubmed
Journal: Immunological investigations
January/14/2010
Abstract
To offer a more effective microencapsulation technique of islets for the treatment of diabetes, we have developed a new type of microcapsule comprising sulphate glucomannan-alginate barium (SGA). We compared it with traditional microencapsulated APA (alginate-poly-L-lysine-alginate) and ABa (Ba(2+)-alginate) microencapsulated islets. These three types of microencapsulated islets were prepared and cultured in vitro and we studied their morphology and activity. To determine their effects on insulin secretion and cytokine production (MCP-1, IL-1, IFN-gamma, TNF-alpha) the islets were transplanted into diabetic rats. There was no difference in the morphologies of the three types of microencapsulated islets or their insulin secretory capacity in vitro. However, the SGA microencapsulated islets had higher activity and produced more insulin than the APA and ABa microencapsulated islets after transplantation. Normoglycemia was maintained for longer in the SGA-transplanted group than in the other two groups. The concentrations of cytokines in the peritoneal fluid were significantly decreased in the SGA group, as was the infiltration of inflammatory cells around the microcapsules. In conclusion, the novel SGA microencapsulated islets can maintain normoglycemia in diabetic rats without immunosuppression for longer than APA and ABa microencapsulated islets.
Pubmed
Journal: Biosensors & bioelectronics
August/18/2008
Abstract
Three-dimensionally (3D) ordered macroporous active carbon has been fabricated and used as electrode substrate for the direct electrochemistry of horse heart cytochrome c (Cyt c). The Cyt c immobilized on the surface of the ordered macroporous active carbon shows a pair of well-defined and nearly reversible redox waves at the formal potential of -0.033V in pH 6.8 phosphate buffer solution. The interaction between Cyt c and the 3D macroporous active carbon makes the formal potential shift negatively compared to that of Cyt c in solution. Spectrophotometric and electrochemical methods have been used to investigate the interaction between Cyt c and the porous active carbon. The immobilized Cyt c maintains its biological activity, and shows a surface controlled electrode process with the electron-transfer rate constant (k(s)) of 17.6s(-1) and the charge-transfer coefficient (a) of 0.52, and displays the features of a peroxidase in the electrocatalytic reduction of hydrogen peroxide (H(2)O(2)). A potential application of the Cyt c-immobilized porous carbon electrode as a biosensor to monitor H(2)O(2) has been investigated. The steady-state current response increases linearly with H(2)O(2) concentration from 2.0x10(-5) to 2.4x10(-4)moll(-1). The detection limit (3sigma) for determination of H(2)O(2) has been found to be 1.46x10(-5)moll(-1).
Authors
Pubmed
Journal: Bioresource technology
September/24/2017
Abstract
Recently, extrusion press treatment shows some promising advantages for effectively separating of organic fraction of municipal solid waste (OFMSW) from the mixed MSW, which is critical for their following high-efficiency treatment. In this study, an extruded OFMSW obtained from a demonstrated MSW treatment plant was characterized, and submitted to a series of semi-continuous anaerobic experiments to examine its biodegradability and process stability. The results indicated that the extruded OFMSW was a desirable substrate with a high biochemical methane potential (BMP), balanced nutrients and reliable stability. For increasing organic loading rates (OLRs), feeding higher volatile solid (VS) contents in feedstock was much better than shortening the hydraulic retention times (HRTs), while excessively high contents caused a low biodegradability due to the mass transfer limitation. For energetics evaluation, a high electricity output of 129.19-156.37kWh/ton raw MSW was obtained, which was further improved by co-digestion with food waste.
Pubmed
Journal: Journal of the neurological sciences
October/20/2013
Abstract
Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disorder of the central nervous system (CNS), which can be monophasic or with repeated episodes. Relapsing ADEM can be misdiagnosed as multiple sclerosis (MS). We describe here a 16-year-old female patient with multiphasic disseminated encephalomyelitis (MDEM), which was exacerbated after an interferon beta (INF-β) treatment. The patient presented with polysymptomatic and encephalopathic features at the first attack and was definitively diagnosed with ADEM. During the following 28months, she had two relapses, with the lesions spatially disseminated in time and space, but without encephalopathy. She was diagnosed with MS and started on treatment with IFN-β injection. A severe relapse occurred 5months after starting IFN-β treatment, with both the clinical and MRI characteristics worse than during the former 2 relapses, meeting the diagnostic criteria for MDEM. Treatment with IFN-β was halted, with no new relapses observed over the following 9months. These findings suggest that treating MDEM patients with IFN-β may exacerbate the disease, similar to that observed during IFN-β treatment of patients with neuromyelitis optica. Caution should be exercised when treating these patients with IFN-β.
Pubmed
Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
October/24/2005
Abstract
OBJECTIVE
To investigate the relationship between tobacco smoking, drinking and p53 alteration in esophageal carcinoma.
METHODS
Literature on the relationship between p53 alteration in esophageal carcinoma and tobacco smoking, drinking through Meta-analysis were reviewed.
RESULTS
In 14 selected papers related to tobacco smoking, pooled odds ratio (OR) of tobacco smoking with P53 overexpression and p53 alteration were 1.99 (95% CI: 1.30- 3.06) and 1.64 (95% CI: 1.13 - 2.37), respectively (P < 0.05). Pooled OR of tobacco smoking with p53 mutation was 1.11 (95% CI: 0.47 - 2.76) (P > 0.05). In 11 selected papers on alcohol drinking, pooled OR of drinking with P53 overexpression, p53 mutation and p53 alteration were 1.30 (95% CI: 0.83 - 2.04), 1.13 (95% CI: 0.67 - 1.90) and 1.22 (95% CI: 0.87 - 1.72) respectively (P > 0.05).
CONCLUSIONS
There were significant relations between tobacco smoking and p53 alteration while there were no significant relations between alcohol drinking and p53 alteration.
Pubmed
Journal: Obesity surgery
October/25/2017
Abstract
This study was conducted to evaluate the prevalence of iron-deficiency anemia (IDA) after Roux-en-Y gastric bypass (RYGB) in Chinese obese patients with type 2 diabetes (T2DM). Furthermore, we evaluate potential predicting factors for onset of IDA after RYGB.
A total of 184 obese T2DM individuals who underwent RYGB were enrolled in the study. Patients were divided into three groups: male, premenopausal female, and postmenopausal female. Hematologic parameters were obtained prior to and after surgery on standardized time intervals up to 24 months postoperatively.
At baseline, 6.0 % of patients were anemic, with similar percentages of anemic patients in each group. The relative decrease in the mean hemoglobin (Hb) level was significantly more pronounced for premenopausal female than for postmenopausal female or male. The percentage of anemia in male group had increased to 15.2 and 17.0 % at 6 and 12 months, respectively, and then decreased to 4.5 % at 24-month visit. In postmenopausal female group, the percentages of anemia constantly increase to 34.0 % at 6-month follow-up. Then, it decreased gradually to 25.0 and 26.7 % at 12- and 24-month visits, respectively. In premenopausal female group, the anemia percentages dramatically increased to 62.5 % at 24-month follow-up. Multiple logistic regression indicated that lower serum ferritin level preoperative and female were associated with higher possibility to suffer IDA 2 years after RYGB.
Iron-deficiency and IDA are extremely frequent after RYGB in Chinese obese patients with T2DM. Premenopausal female presents unexpectedly high incidence of IDA during the 2-year observation.
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