K Takahashi
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Pubmed
Journal: Annales de gastroenterologie et d'hepatologie
November/24/1970
Pubmed
Journal: Gifu Shika Gakkai zasshi = The Journal of Gifu Dental Society
October/28/1982
Pubmed
Journal: Gan to kagaku ryoho. Cancer & chemotherapy
September/19/1983
Abstract
The clinical effects of chemoimmunotherapy including levamisole on advanced gastrointestinal cancer were evaluated. A total of 81 patients with histologically proved advanced gastrointestinal cancer including 67 cases of stomach carcinoma entered in this study. They were divided randomly into the control group on the two-drug regimen of 5-FU (250 mg/body/day, i.v. daily) and adriamycin (20 mg/m2/day, i.v. on days 1 and 2, q. 3 wks.) and the levamisole group on the three-drug regimen of above two drugs plus levamisole (150 mg/body/day, p.o. on days 5, 6 and 7, q. 2 wks.). Forty cases were allocated to the control group, and 41 cases to the levamisole group. No significant difference was observed in terms of a response rate between these two groups, though the response rate was slightly higher in the levamisole group (21.7%) than in the control group (10.5%). The median duration of response was 119 days in the levamisole group and 77 days in the control group. Therefore, it indicated that longer duration of response was obtained by using chemoimmunotherapy including levamisole compared to chemotherapy alone. The 50% survival time was significantly prolonged in the levamisole group (199 days) compared with the control group (118 days). Incidence of nausea and vomiting among the side effects by the regimens was significantly higher in cases on a three-drug regimen than those on a two-drug regimen. The results obtained in the present studies suggest that levamisole in combination with anticancer agents prolong the duration of response and the survival of the patients with advanced gastrointestinal or stomach carcinoma.
Pubmed
Journal: Nihon Geka Gakkai zasshi
December/12/1985
Abstract
Mass screening for breast cancer which was commenced by Miyagi Cancer Society in 1977 has been carried out on 94953 examinees. The main activities comprise itinerant screening in the communities and group screening at the workplaces. In addition to two types of mass screening, examination was also performed at the detection center. The overall breast cancer detection rate was 0.12% in mass screening. In contrast it was 3.1% at the center. Early breast cancer, however, was more frequently found in mass screening than at the center examination. The cytologic studies of nipple discharge were performed on 14314 subjects as first screening. Positive finding was seen in 5 (0.005%). In high risk group, which also underwent mammography at first screening, the detection rate was higher than that among general examinees. Method for effective procedures for detecting early breast cancer are now under study.
Pubmed
Journal: Nihon juigaku zasshi. The Japanese journal of veterinary science
August/24/1980
Pubmed
Journal: Nihon Sanka Fujinka Gakkai zasshi
September/13/1984
Abstract
Mass screenings for uterine cancer have been done on 200,000 women in Shimane Prefecture, Japan, from 1972-1981. Up to 1978, a cotton-tipped applicator was used for sample procurement and since that time a wooden spatula type instrument has been used. A central, cytological diagnostic system has been used since 1979. The cytology activity index (CAI) was about 90 each year. The rate of second examination performed is about 60% for women requiring an accurate examination. Cancer detection rates increased from 0.05% to 0.12%, the false negative rate decreased, cytological and histological findings were in close parallel and the mortality rates have decreased. These positive results are attributed to the use of the wooden spatula and central diagnostic systems. By the mass screening for uterine cancer during these 10 years, 81 women were detected as having carcinoma in situ and 107 women as having invasive carcinoma in the histological findings. The number of first screenings has decreased gradually, but the number examined 6 times or more has increased. These results include that same women have tended to undergo the mass screening examination. In women over 50 y.o., particularly those 60 or over, the number screened was low, yet the incidence of invasive cancer exceeded that in other groups.
Pubmed
Journal: The Japanese journal of antibiotics
September/27/1984
Abstract
Biological effect of bestatin in combination with bleomycin against rat ascites hepatoma AH 66 was investigated. The combined use of bestatin and bleomycin both at a dose of 0.5 mg/kg was found to have a strong inhibition of the tumor growth. The combined effect was also confirmed histologically as follows. In combination group, increase of necrobiosis area in the tumor lesion, augmentation of infiltration of lymphocytes and macrophages around the solid tumors, and marked replacement of necrotic area by fibrous granular lesion were stronger and more rapidly than that in the other group.
Pubmed
Journal: Neurologia medico-chirurgica
October/24/1984
Pubmed
Journal: Nihon Jinzo Gakkai shi
December/16/1986
Pubmed
Journal: Nihon Kyobu Shikkan Gakkai zasshi
August/19/1981
Pubmed
Journal: Cancer
October/3/1985
Abstract
Since 1977, mass screening for breast cancer has been conducted in Miyagi Prefecture, Japan. The main activities consist of itinerant screening in the communities and group screening at the workplace. In addition, examinations were also carried out at a detection center. The total number of subjects examined was 90,076 in mass screening, with 4172 (4.6%) of them requiring a second examination. The overall breast cancer detection rate was 0.12% in the mass screening. In contrast, it was 3.1% at the center examination. Cytologic studies of nipple discharge were performed on 31,833 subjects. Positive findings were seen in 4 (0.004%). The incidence of smaller tumors was higher and that of nodal metastasis was lower in subsequent examinations than in the initial screening. In the high-risk group, who also underwent mammography at first screening, the detection rate was higher than that among general subjects examined.
Pubmed
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
May/22/1986
Pubmed
Journal: Radioisotopes
October/24/1981
Pubmed
Journal: Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica
May/4/1989
Pubmed
Journal: Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society
January/16/1989
Pubmed
Journal: Transplantation proceedings
September/23/1987
Pubmed
Journal: Leukemia
December/6/1999
Abstract
In a 27-year-old female with Turner syndrome mosaic, Philadelphia (Ph) chromosome-positive chronic myeloid leukemia (CML) occurred only in the monosomic cells (45, Xc). Extensive cytogenetic studies, including triple-color fluorescence in situ hybridization (FISH), revealed that Ph-positive monosomic cells (45, Xc), Ph-negative monosomic cells and normal diploid cells (46, XX) were present in her bone marrow at diagnosis. After successful interferon therapy, the non-leukemia cells expanded and reconstituted normal hematopoiesis resulting in complete cytogenetic response, following the selective suppression of the monosomic Ph-positive leukemia clone. The ratio of Xc to XX cells in bone marrow cells was significantly increased to that in skin fibroblasts. Moreover, the ratio of Ph-positive cells to Ph-negative cells was found to be significantly different between karyotyping and FISH. Studies of this quite unique case not only confirmed the clonality of CML, effectiveness of interferon-alpha and X chromosome imbalance among different tissues, but also demonstrated a discrepant increase of the BCR/ABL-positive clone in CML. The latter supports the hypothesis that reduced programmed cell death may be the primary mechanism responsible for the expansion of the leukemia clone in CML. Our study verifies the importance of extensive analysis of a neoplastic disease in patients with a constitutional chromosomal abnormality.
Pubmed
Journal: Stroke
January/24/2001
Abstract
OBJECTIVE
Poly(ADP-ribose) polymerase (PARP) is important in modulating inflammation, which has been implicated in cerebral vasospasm after subarachnoid hemorrhage (SAH). We investigated the role of PARP in vasospasm using 3-aminobenzamide (3-AB), a PARP inhibitor, in a rabbit model.
METHODS
Twenty-four New Zealand White rabbits were divided into 4 groups: (1) no treatment (control group, n=6); (2) blood injection without pretreatment (SAH-only group, n=6); (3) blood injection with pretreatment by vehicle (SAH+vehicle group, n=6); and (4) blood injection with pretreatment by 3-AB (SAH+3-AB group, n=6). We used the single-hemorrhage model of SAH, injecting autologous arterial blood into the cisterna magna. Angiography was performed before (baseline) and after (day 2) SAH, and the diameter of the basilar artery (BA) was measured. Animals were euthanatized after the second angiogram. After perfusion and fixation, the brains were cut into sections for hematoxylin and eosin and immunohistochemical staining for poly(ADP-ribosyl)ation.
RESULTS
In the control group, there were no differences in the BA lumen caliber between baseline and day 2 (96.8+/-10.4%). Cerebral vasospasm in the SAH+3-AB group (88.2+/-6. 2%) was remarkably attenuated in comparison with that in the SAH-only group (64.9+/-8.0%) and the SAH+vehicle group (65.6+/-10. 8%). The BA in the SAH+3-AB group showed less corrugation of the tunica elastica interna than that in the SAH-only and SAH+vehicle groups. Staining for poly(ADP-ribosyl)ation was markedly inhibited in smooth muscle and adventitial cells of the BA in the SAH+3-AB group compared with other groups.
CONCLUSIONS
Inhibiting ADP-ribosylation attenuates cerebral vasospasm after SAH in rabbits, and PARP activation may play an important role in the development of cerebral vasospasm.
Pubmed
Journal: Nihon Geka Gakkai zasshi
December/25/1984
Abstract
This study was undertaken to clarify the intrahepatic bile flow mechanism in man. The fasting cholescintigraphy was obtained from 40 healthy controls and 5 patients with hepatolithiasis by injection of 2 m Ci of 99mTc-EHIDA. The serial analog images were recorded at each 5 min for 1 hr and the radioactivity was simultaneously counted by a computer connected with a gamma camera at 1 frame per 15 sec. Results obtained are summarized as follows: The analog images and dynamic curves obtained from 32 out of 40 controls demonstrated that the bile flow of the left hepatic duct was significantly delayed than that of the right hepatic duct, and this seemed to coincide with the high incidence of left intrahepatic gallstones. The bile flow was always hampered throughout the biliary tracts in 5 cases of hepatolithiasis regardless of location of stones. Proximal drainage (hepatic portojejunostomy) and distal drainage (transduodenal sphincteroplasty) showed excellent drainage effects on the recovery of the disturbed bile flow in those patients.
Pubmed
Journal: American journal of veterinary research
December/27/1994
Abstract
Parenchymal cells were isolated from the liver of male calves, and monolayer cultures formed were treated with glucocorticoids to examine whether haptoglobin, appearance of which is associated with hepatic lipidosis (fatty liver) in cattle, is induced by steroid hormones. Without addition of dexamethasone, only trace amounts of haptoglobin were detected in culture medium. With addition of dexamethasone (10(-12) to 10(-4) M), considerable amounts of haptoglobin were released into the medium. Maximal release was observed at concentrations of 10(-8) to 10(-6) M dexamethasone. Haptoglobin release was similarly induced by cortisol, although the effect was less potent than that of dexamethasone. Actinomycin D (a known protein synthesis inhibitor) dose-dependently reduced amounts of haptoglobin released in response to 10(-8) M dexamethasone. Dexamethasone also induced annexin I, which is known to be synthesized in response to glucocorticoids. Dexamethasone treatment resulted in reduced protein kinase C activity in the cell cytosol, which has been shown to be an early event in dexamethasone-treated cells. Other than glucocorticoids, estradiol induced haptoglobin release, whereas progesterone was less effective. The association of haptoglobin with hepatic lipidosis can be reasonably explained by the fact that haptoglobin production by the liver is induced by glucocorticoids and estradiol, and these steroid hormones are triggers for development of hepatic lipidosis in cattle.
Pubmed
Journal: Headache
December/15/1994
Abstract
The aim of this study was to clarify the changes of inhibitory interneuronal activity in patients with chronic tension-type headache with disorder of pericranial muscle after treatment, and the pharmacological mechanisms of tizanidine--an alpha 2 adrenergic agonist. The effects of tizanidine on exteroceptive suppression (ES) of the temporalis muscle were examined in eighteen patients with chronic tension-type headache with disorder of pericranial muscles, before and two weeks after the administration of tizanidine. The left mental nerve was stimulated, under the maximal voluntary contraction of the temporalis muscles. Two types of stimulation were used: weak stimulation with four times the sensory threshold, and strong stimulation with 10 times the sensory threshold. The rectified electromyographic activity was recorded from the right temporalis muscle. ES2 produced by four times the sensory threshold was lengthened after tizanidine administration. This fact suggests that tizanidine improves the inhibitory function in the central nervous system, and then relieves headache. However, ES produced by 10 times the sensory threshold did not change. This suggests that the effect of tizanidine may be relatively mild. The interneurones mediating ES2 may be modified by the alpha 2 agonist.
Pubmed
Journal: Nippon Ganka Gakkai zasshi
April/25/2001
Abstract
BACKGROUND
We report a rare case of a 69-year-old woman with malignant melanoma of her right socket, who had undergone evisceration of her right globe for unknown reasons at the age of 6.
METHODS
A 69-year-old woman presented with the complaint of inability to keep the prosthesis in her socket. A large blackish brown mass was seen behind the eyelids, and biopsy of this tissue revealed a mixed type malignant melanoma. A right exenteration was performed and histopathologic examination demonstrated a large tumor mass anterior and adjacent to the remains of the eviscerated globe.
CONCLUSIONS
During evisceration, uveal pigment may be incompletely removed from the globe, or may be inadvertently scattered in the orbit. This case may demonstrate the development of a malignant melanoma from the uvea of an eviscerated globe. We recommend that careful long-term follow-up be performed on patients who have undergone evisceration.
Pubmed
Journal: Bioscience, biotechnology, and biochemistry
July/20/1999
Abstract
An effective host-vector system specific to the yeast Saccharomyces exiguus Yp74L-3 was constructed to promote the molecular genetic analyses for the yeast. To obtain a stable reversionless host strain, we constructed an S. exiguus strain carrying leu2::ScURA3 by disrupting the S. exiguus LEU2 gene with the S. cerevisiae URA3 gene. A vector plasmid unique to S. exiguus was subsequently developed by inserting both the LEU2 gene and an ARS cloned from S. exiguus into an Escherichia coli phagemid, pUC119. The vector constructed, pTH119 was able to transform the S. exiguus leu2::ScURA3 strain to Leu+ efficiently. The stability of the vector in the S. exiguus host cells resembled that of a YRp-type vector in S. cerevisiae.
Pubmed
Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
November/9/1986
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