Yang Liu
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Publication
Journal: The Journal of international medical research
November/11/2018
Abstract
OBJECTIVE
Prevention of postoperative cognitive dysfunction (POCD) in patients of advanced age remains unclear. Studies have shown that the cholinergic anti-inflammatory pathway contributes to a decreased risk of POCD and that nicotine stimulates the cholinergic anti-inflammatory pathway. We investigated whether patients of advanced age with a preoperative smoking history have a decreased risk of POCD.
METHODS
In total, 382 patients (190 smokers, 192 nonsmokers) aged ≥60 years who underwent major noncardiac surgery were enrolled. Cognitive function was assessed, and multivariate logistic regression analyses were performed to identify risk factors.
RESULTS
On postoperative days 5 and 7, 111 (29.05%) and 90 (23.56%) patients exhibited POCD, respectively. A preoperative smoking history was significantly correlated with a decreased risk of POCD. A high serum tumor necrosis factor-α (TNF-α) level on the operative day was significantly associated with an increased risk of POCD. Early POCD was significantly associated with the sufentanil dosage, age, and education level. The hospital stay in patients with and without POCD was 10.54 ± 2.03 and 8.33 ± 1.58 days, respectively.
CONCLUSIONS
A preoperative smoking history was associated with a decreased risk of early POCD, and a high serum TNF-α level was significantly associated with an increased risk of POCD.
Publication
Journal: Blood advances
November/12/2018
Abstract
The efficacy of traditional chemotherapy is limited by its toxicity, especially with regard to hematopoiesis. Here we show that miR-26a plays a critical role in protecting mice against chemotherapy-induced myeloid suppression by targeting a proapoptotic protein (Bak1) in hematopoietic stem/progenitor cells (HSPCs). Because c-Kit is expressed at high levels in HSPCs, we designed a microRNA-aptamer chimera that contains miR-26a mimic and c-Kit-targeting aptamer and successfully delivered miR-26a into HSPCs to attenuate toxicity of 5' fluorouracil (5-FU) and carboplatin. Meanwhile, our in silico analysis revealed widespread and prognosis-associated downregulation of miR-26a in advanced breast cancer and also showed that KIT is overexpressed among basal-like breast cancer cells and that such expression is associated with poor prognosis. Importantly, the miR-26a aptamer effectively repressed tumor growth in vivo and synergized with 5-FU or carboplatin in cancer therapy in the mouse breast cancer models. Thus, targeted delivery of miR-26a suppresses tumor growth while protecting the host against myelosuppression by chemotherapy.
Publication
Journal: Evidence-based complementary and alternative medicine : eCAM
May/7/2014
Abstract
Ethnopharmacological Relevance. TZQ-F has been traditionally used in Traditional Chinese Medicine as a formula for the treatment of diabetes. Aim of the Study. This study aims to compare the pharmacologic effects and gastrointestinal adverse events between TZQ-F and acarbose. Methods. The double-blind randomized placebo-controlled fivefold crossover study was performed in 20 healthy male volunteers. Plasma glucose, plasma IRI, and plasma C-peptide were measured to assess the pharmacologic effects. Flatus and bowel activity were measured to assess the adverse event of gastrointestinal effect. Results. 3 and 4 tablets of TZQ decreased the C max of plasma glucose compared with that of the previous day and with placebo. 3 tablets also decreased C max of plasma C-peptide compared with placebo. 4 tablets increased C max of plasma insulin after breakfast and the AUC of plasma C-peptide after breakfast and dinner. 2 tablets did not decrease plasma glucose and elevated the C max and AUC of C-peptide after breakfast and dinner, respectively. Acarbose 50 mg decreased the C max of plasma insulin and C-peptide after breakfast and the C max of plasma glucose and C-peptide after dinner. The subjects who received TZQ did not report any abdominal adverse events. Conclusions. 3 tablets of TZQ have the same effects as the acarbose.
Publication
Journal: Nanoscale
August/12/2018
Abstract
Rhenium disulfide (ReS2) is a recently discovered next-generation transition metal dichalcogenides (TMDs) material that exhibits unique properties, which have resulted in its wide use in the fabrication of electronic and optoelectronic devices. Studies on ReS2 have mainly focused on the synthesis and applications of two-dimensional (2D) materials, while studies on one-dimensional (1D) ReS2 have yet to be reported. Herein, 1D single-crystal ReS2 nanowires have been synthesized successfully for the first time via chemical vapor deposition (CVD) and utilized as the active layer in a nanostructured photodetector. The crystal structure, phonon vibration modes, and chemical states of the single-crystal ReS2 nanowires have been investigated. Furthermore, the nanostructured photodetector using single-crystal ReS2 nanowires as the active layer and Ag nanowire networks as the transparent electrodes exhibited excellent performance, including a higher photoresponsivity (5.08 × 105), the highest external quantum efficiency (1.07 × 106), and the largest specific detectivity (6.1 × 1015) among ReS2 nanostructure-based photodetectors reported to date. Furthermore, the photodetector performance under vacuum conditions was investigated, which provides some information on the work mechanism of the ReS2 photodetector.
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Publication
Journal: International journal of biological macromolecules
November/19/2018
Abstract
The antioxidant activities of carboxymethylated polysaccharide from cushaw were investigated. The cushaw polysaccharide was extracted by hot water method and deproteinized with CaCl2. There was a peak around 178 in 13C NMR spectrum, which proved that the preparation of carboxymethyl cushaw polysaccharide was successful. At the same time, it indicated that the carboxymethylated cushaw polysaccharide had better ability to scavenge superoxide anions and hydroxyl radicals.
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Publication
Journal: Journal of hazardous materials
September/20/2018
Abstract
This paper investigated fluidized bed pyrolysis (FBP) and microwave-assisted auger pyrolysis (MWAP) for treatment and disposal of textile dyeing sludge (DS), and the products were analyzed and compared. MWAP achieved higher yields of char and condensate, and lower non-condensable gas yields compared to FBP. The yields of CO2 from FBP were much higher than those from MWAP at 450-850 °C. Whereas the yields of H2, CO and CH4 from MWAP were greater than those from FBP at higher temperature (e.g. 850 °C). The maximum condensate yields of FBP and MWAP were observed at 650 °C. Pyrolysis oil of MWAP contained less of macromolecules compared to FBP. Pyridine, phenol, aniline and their derivatives were major components in MWAP oil. Pyridine was the dominant oil component at 850 °C for FBP. Most of nitrogen-, sulfur- and chlorine-containing compounds were retained in FC (FBP char) and MC (MWAP char), and higher relative proportion (RP) of nitrogen, sulfur and chlorine were observed in the condensate and non-condensable gas from MWAP in comparison with FBP. FBP and MWAP both decreased risk degrees of heavy metals compared to raw DS, and heavy metals in FC and MC posed slight risk to the environment based on national standards in China.
Publication
Journal: Current eye research
August/16/2018
Abstract
OBJECTIVE
The purpose of this study is to establish the short tandem repeat (STR) profiles of several human cell lines commonly used in ocular surface research.
METHODS
Independently DNA was extracted from multiple passages of three human corneal epithelial cell lines, two human conjunctival epithelial cell lines and one meibomian gland cell line, from different laboratories actively involved in ocular surface research. The samples were then subjected to STR analysis on a fee-for-service basis in an academic setting and the data compared against that in available databases.
RESULTS
The STR profiles for the human corneal epithelial cells were different among the three cell lines studied and for each line the profiles were identical across the samples provided by three laboratories. Profiles for the human conjunctival epithelial cells were different among the two cell lines studied. Profiles for the meibomian gland cell line were identical across the samples provided by three laboratories. No samples were contaminated by elements of other cell lines such as HeLa.
CONCLUSIONS
This comprehensive study provides verification of STR profiles for commonly used human ocular surface cell lines that can now be used as a reference by others in the field to authenticate the cell lines in use in their own laboratories.
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Publication
Journal: Chinese medical journal
December/2/2013
Abstract
This case report describes a 44-year-old woman with primary spinal cord malignant melanoma localized in the lumbar region. This is a very rare lesion. The patient presented with back pain and slight weakness in her lower extremities. Magnetic resonance imaging showed hyperintense signals on T1-weighted images and hypointense signals on T2-weighted images. The entire tumor was removed surgically. The patient's postoperative clinical examination revealed mild neurological improvements. Histopathological investigations confirmed the tumor was a malignant melanoma. When treating common lesions of the lumbar spinal cord with a benign appearance, surgeons should be aware of the potential for malignant tumors.
Publication
Journal: Applied and environmental microbiology
November/13/2018
Abstract
Polyoxin (POL) is an unusual peptidyl nucleoside antibiotic, in which the peptidyl moiety and nucleoside skeleton are linked by an amide bond. However, their biosynthesis remains poorly understood. Here, we report the deciphering of PolG as an ATP-dependent ligase responsible for the assembly of POL. A polG mutant is capable of accumulating multiple intermediates, including the peptidyl moiety (carbamoylpolyoxamic acid [CPOAA]) and the nucleoside skeletons (POL-C and the previously overlooked thymine POL-C). We further demonstrate that PolG employs an ATP-dependent mechanism for amide bond formation and that the generation of the hybrid nucleoside antibiotic POL-N is also governed by PolG. Finally, we determined that the deduced ATP-binding sites are functionally essential for PolG and that they are highly conserved in a number of related ATP-dependent ligases. These insights have allowed us to propose a catalytic mechanism for the assembly of peptidyl nucleoside antibiotic via an acyl-phosphate intermediate and have opened the way for the combinatorial biosynthesis/pathway engineering of this group of nucleoside antibiotics.IMPORTANCE POL is well known for its remarkable antifungal bioactivities and unusual structural features. Actually, elucidation of the POL assembly logic not only provides the enzymatic basis for further biosynthetic understanding of related peptidyl nucleoside antibiotics but also contributes to the rational generation of more hybrid nucleoside antibiotics via synthetic biology strategy.
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Publication
Journal: Journal of otology
November/13/2018
Abstract
UNASSIGNED
To report a scala tympani drill-out technique for managing malformed facial nerve covering the entire oval window (OW).
UNASSIGNED
Data from three cases with OW atresia, malformed stapes and abnormal facial nerve courses were reported, in which a scala tympani drill-out technique was employed with a TORP between the tympanic membrane and scala tympani fenestration for hearing reconstruction.
UNASSIGNED
Air conduction hearing improved in two of the three cases following surgery. In the third case, there was no improvement in air conduction hearing following a canal wall up mastoidectomy and tympanoplasty. There were no vertigo, tinnitus or sensorineural hearing loss in the three cases.
UNASSIGNED
The scala tympani drill-out technique, which is basically fenestration at the initial part of the basal turn, provides a choice in hearing reconstruction when the OW is completely covered by abarrently coursed facial nerve.
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Publication
Journal: Veterinary journal (London, England : 1997)
May/2/2012
Abstract
Contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides small colony type, was once the most damaging infectious animal disease in China, second only to rinderpest. Between 1949 and 1989, 178,570 cattle died of CBPP, causing estimated losses of 356 million RMB (1RMB=approx. £0.094, US$0.15, €0.11 at 27th January 2011). In 1956, in an effort to control the disease, a virulent strain of the causative organism (Ben-1) was attenuated by multiple passages in rabbits. The resultant vaccine achieved a high protection rate in cattle with a duration of immunity of 28 months. Vaccines were also prepared in sheep to increase the antigen yield and then in Tibetan sheep because it caused fewer adverse reactions in yaks and related species. The last CBPP infected animal was identified in 1989 since when no more cases have occurred. In 1992, vaccination of cattle was stopped. In 2008 China submitted an application to the World Organization for Animal Health (OIE) to be declared CBPP-free.
Publication
Journal: Journal of anesthesia
October/31/2019
Abstract
The present study was designed to compare the feasibility of ultrasound (US)-guided lumbar epidural access using paramedian sagittal scanning (PMSS) and paramedian transverse scanning (PMTS) approaches.Fifty patients undergoing surgery of the lower extremities were randomly allocated into 2 groups. The patients in PMSS group received PMSS-guided in-plane epidural access, whereas patients in PMTS group received PMTS-guided in-plane epidural access. The US visibility of neuraxial structures and of Tuohy needle during US scout scan, procedure duration, the number of attempts to access epidural space, Tuohy needle puncture depth in the epidural space, and extent of sensory block after spinal block between two groups were compared.The US visibility of Tuohy needle and neuraxial structures was comparable between two groups. There was an overall decrease in procedure duration in the PMTS group relative to the PMSS group (360 ± 42 vs. 490 ± 38 s). The number of attempts needed to access the epidural space in PMSS group was significantly higher than in PMTS group. Distances between the epidural space and the puncture site in PMSS group and PMTS group showed a significant difference (7.13 ± 0.67 vs. 5.24 ± 0.21 cm). No significant differences in the extent of sensory block after spinal block were observed.We found that PMTS approach was superior as a means of achieving epidural access relative to the PMSS approach, since PMTS approach can be conducted more quickly given shorter path of the needle and less times needed for epidural access during this procedure.Chinese Clinical Trial Registry, clinical trial number ChiCTR1800015815, date of registration April 24, 2018.
Publication
Journal: Bioorganic & medicinal chemistry letters
January/3/2013
Abstract
A novel diamino/dicationic polyamide f-Im(*)PyIm (5) that contains an orthogonally positioned aminopropyl chain on an imidazole (Im(*)) moiety was designed to target 5'-ACGCGT-3'. The DNA binding properties of the diamino polyamide 5, determined by CD, ΔT(M), DNase I footprinting, SPR, and ITC studies, were compared with those of its monoamino/monocationic counterpart f-ImPyIm (1) and its diamino/dicationic isomer f-ImPy(*)Im (2), which has the aminopropyl group attached to the central pyrrole unit (Py(*)). The results gave evidence for the minor groove binding and selectivity of polyamide 5 for the cognate sequence 5'-ACGCGT-3', and with strong affinity (K(eq)=2.3×10(7) M(-1)). However, the binding affinities varied according to the order: f-ImPy(*)Im (2)>f-ImPyIm (1)≥f-Im(*)PyIm (5) confirming that the second amino group can improve affinity, but its position within the polyamide can affect affinity.
Publication
Journal: ACS applied materials & interfaces
July/29/2018
Abstract
The oxygen evolution reaction (OER) is an essential process for renewable energy, and designing a bifunctional oxygen electrocatalyst with high catalytic performance plays a significant role. In this work, FeS, Ni3S2, Fe5Ni4S8, and N, O, S-doped meshy carbon base were successfully synthesized. The sample containing Fe5Ni4S8 exhibited excellent OER performance. The density functional theory calculations indicate that the partial density of states for 3d electrons (3d-PDOS) of Fe and Ni atoms are changed from monometallic sulfide to bimetallic sulfide at the sulfur vacancy. The asymmetric 3d electronic structure optimizes the 3d-PDOS of Fe and Ni atoms, and leads to an enhanced OER activity. This work provides a new strategy to prepare a low-cost electrocatalyst for oxygen evolution with high-efficiency.
Publication
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
May/28/2019
Abstract
In this study, we report a new compound, (E)-4-(((2-hydroxynaphthalen-1-yl)methylene)amino)-3-methylbenzoic acid (HNMB), which shows aggregation-induced emission property as well as intramolecular charge transfer (ICT) nature. In addition, it exhibits unique mechanochromic luminescence (MCL). The HNMB solid powder emits strong emission but shows quenching effect together with bathochromic-shift after grinding, suggesting a high contrast ratio up to 1420%. Through crystallographic analysis, the relationship between MCL nature and molecular packing mode is verified: Molecules in crystalline phase adopt the J-type coupling based on less overlapped π⋯π stacking, in which multiple intermolecular interactions mainly including C-H⋯π, C-H⋯O and hydrogen bonding, help to stabilize such packing mode. When these interactions are destructed by mechanical force, the packing would be disassembled, activating the MCL behavior. Such working mechanism only needs weak external force capable of destructing intermolecular interactions, rendering the MCL material highly sensitive to pressure. As a practical application, a film sensor for pressure detection is designed based on HNMB, which gives a linear relation between the emission intensity and the external pressure in a lower range. The detection limit of the film sensor is 27.24 Mpa, suggesting high sensitivity. In addition, pressure mapping with high contrast ratio is obtained by surface plot, making this pressure sensor a reliable candidate to be instrumented for various applications.
Publication
Journal: Sensors (Basel, Switzerland)
July/25/2019
Abstract
Amid the ever-accelerated development of wireless communication technology, we have become increasingly demanding for location-based service; thus, passive indoor positioning has gained widespread attention. Channel State Information (CSI), as it can provide more detailed and fine-grained information, has been followed by researchers. Existing indoor positioning methods, however, are vulnerable to the environment and thus fail to fully reflect all the position features, due to limited accuracy of the fingerprint. As a solution, a CSI-based passive indoor positioning method was proposed, Wavelet Domain Denoising (WDD) was adopted to deal with the collected CSI amplitude, and the CSI phase information was unwound and transformed linearly in the offline phase. The post-processed amplitude and phase were taken as fingerprint data to build a fingerprint database, correlating with reference point position information. Results of experimental data analyzed under two different environments show that the present method boasts lower positioning error and higher stability than similar methods and can offer decimeter-level positioning accuracy.
Publication
Journal: ISA transactions
May/24/2019
Abstract
The congestion control problem of TCP network systems with user datagram protocol (UDP) flows is investigated in this paper. A nonlinear TCP network model with strict-feedback structure is first established. The unknown UDP flow is regarded as the external disturbance, and the maximum UDP flow is calculated by using the minimax approach. And then, a congestion control algorithm is proposed by using the adaptive backstepping approach. Meanwhile, the adaptive law is employed to estimate the unknown link capacity. The design of the adaptive law is to introduce a parameter mapping mechanism to limit the parameter identification range to a specified interval, thereby improving the estimation efficiency of the parameters. Furthermore, a state-feedback congestion controller is presented to make sure that the output of the system tracks the desired queue. The simulation results show the superiority and feasibility of the proposed method.
Publication
Journal: The Journal of the Acoustical Society of America
November/13/2018
Abstract
Nonlinear ultrasonic guided waves have been investigated widely in closed waveguides such as plates, pipes, etc. However, the description of nonlinear ultrasonic guided waves remains challenging for open waveguides, as energy may leak into the surrounding medium. In this work, the properties of nonlinear ultrasonic guided waves in open waveguides are investigated. Mathematical framework is first established based on real reciprocity relation and modal expansion with perfectly matched layers. Numerical models are then implemented, including nonlinear semi-analytical finite element (SAFE) method to predict the properties of nonlinear ultrasonic guided waves, and time domain finite element models to simulate the nonlinear guided wave propagation and cross validate the predictions from the nonlinear SAFE method. Two examples, an aluminum plate attached to an elastomer and an aluminum plate with water loaded on one side, are studied to demonstrate the proposed methods and reveal some interesting phenomena that only exist in open waveguides. It is interesting to find out that the amplitude of the attenuated second harmonic wave in immersed waveguides can keep constant with propagation distance, only if the primary wave is non-leaky, which may bring potential non-destructive test applications for underwater inspections. Such a feature is validated by well-designed experiments in one-sidedly immersed plates.
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Publication
Journal: Applied optics
November/1/2019
Abstract
Fluorescence imaging systems are regularly characterized by their ability to distinguish varying concentrations of fluorophores in a solution or tissue phantom. However, there is inadequate standardization in the field for fluorescence characterization. In this study, we characterize a fluorescence imaging system developed for pathogen detection, regarding its ability to detect a near-infrared dye. During this process, we vary a number of key factors involved in fluorescence imaging, such as the excitation intensity, background level, working distance, volume of fluorescent solution, and type of container used to hold the fluorescent solution. We then analyze the results, with statistical rigor, to determine which factors result in significant changes in fluorescence detection. Notably, we found that using different types of containers to hold the dye solution can have a significant impact on fluorescence detection, while the effects of working distance and excitation intensity can vary. Based on our findings, greater standardization, or at least more thorough reporting of the experimental setup, is recommended to researchers when publishing characterization results of new imaging systems.
Publication
Journal: Scientific reports
November/5/2019
Abstract
This study aimed to examine hTERC gene in different grades of cervical intraepithelial neoplasia (CIN) and cervical cancer, and the association between hTERC and high risk-human papillomavirus (HR-HPV) infection. Patients who underwent cervical cancer screening at the Second Affiliated Hospital of Kunming Medical University between October 2010 and December 2011 were enrolled. All patients underwent liquid-based cytology test and hybrid capture 2 (HC2) for HPV detection. hTERC was examined using fluorescence in situ hybridization (FISH). Cervical colposcopy biopsy was performed if any of the three results was positive. HC2, FISH, and pathology were compared. A total of 1200 women underwent screening, 150 patients underwent cervical biopsy: 32 in the normal group, 38 in the CIN1 group, 66 in the CIN2/3 group, and 14 in the invasive cervical cancer group. More patients had HR-HPV infection in the CIN2/3 group and ICC group compared with the CIN1 group. hTERC increased with increasing histological dysplasia. There was significant difference in hTERC positive rate between each of the three groups. More patients with hTERC gene amplification were observed in the positive HR-HPV group than in the HR-HPV negative group. In conclusion, hTERC is a potential marker for precancerous cervical cancer lesions. hTERC might be correlated with HR-HPV infection in cervical diseases.
Publication
Journal: Cancer immunology, immunotherapy : CII
October/25/2019
Abstract
Acute myeloid leukemia (AML) is a common and lethal hematopoietic malignancy that is highly dependent on the bone marrow (BM) microenvironment. Infiltrating immune and stromal cells are important components of the BM microenvironment and significantly influence the progression of AML. This study aimed to elucidate the value of immune/stromal cell-associated genes for AML prognosis by integrated bioinformatics analysis. We obtained expression profiles from The Cancer Genome Atlas (TCGA) database and used the ESTIMATE algorithm to calculate immune scores and stromal scores; we then identified differentially expressed genes (DEGs) based on these scores. Overall survival analysis was applied to reveal common DEGs of prognostic value. Subsequently, we conducted a functional enrichment analysis, generated a protein-protein interaction (PPI) network and performed an interrelation analysis of immune system processes, showing that these genes are mainly associated with the immune/inflammatory response. Finally, eight genes (CD163, CYP27A1, KCNA5, PPM1J, FOLR1, IL1R2, MYOF, VSIG2) were verified to be significantly associated with AML prognosis in the Gene Expression Omnibus (GEO) database. In summary, we identified key microenvironment-related genes that affect the outcomes of AML patients and might serve as therapeutic targets.
Publication
Journal: The journal of physical chemistry. B
November/20/2018
Abstract
5-Methylcytosine (5mC) is the predominant epigenetic modification of DNA. 5mC and its sequential oxidation product, 5-hydroxymethylcytosine (5hmC), are crucial epigenetic markers which have a profound impact on gene stability, expression, and regulation. In the present work, ab initio electronic structure computations were performed to investigate the excited-state decay pathways for 5mC and 5hmC in both the neutral and protonated forms. Based on the theoretical quantities, four nonradiative decay pathways via conical intersections (CIs) were identified: ring distortion, ring opening, N-H dissociation, and intersystem crossing (ISC) pathways. Additional calculated potential energy surfaces revealed that ring distortion and ISC pathways were the most effective routes for 5mC and 5hmC, respectively. The influence of environmental factors, such as the solution and an acidic environment, was also explored in this study. Our study demonstrated that excited-state decay pathways via CIs are indispensable for the photostability of DNA epigenetic modifications and may be involved in ingenome stability and mammalian development.
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Publication
Journal: Proceedings of the National Academy of Sciences of the United States of America
December/4/2018
Abstract
The ubiquitin-like protein ubiquilin 2 (UBQLN2) has been genetically and pathologically linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but its normal cellular functions are not well understood. In a search for UBQLN2-interacting proteins, we found an enrichment of stress granule (SG) components, including ALS/FTD-linked heterogeneous ribonucleoprotein fused in sarcoma (FUS). Through the use of an optimized SG detection method, we observed UBQLN2 and its interactors at SGs. A low complexity, Sti1-like repeat region in UBQLN2 was sufficient for its localization to SGs. Functionally, UBQLN2 negatively regulated SG formation. UBQLN2 increased the dynamics of FUS-RNA interaction and promoted the fluidity of FUS-RNA complexes at a single-molecule level. This solubilizing effect corresponded to a dispersal of FUS liquid droplets in vitro and a suppression of FUS SG formation in cells. ALS-linked mutations in UBQLN2 reduced its association with FUS and impaired its function in regulating FUS-RNA complex dynamics and SG formation. These results reveal a previously unrecognized role for UBQLN2 in regulating the early stages of liquid-liquid phase separation by directly modulating the fluidity of protein-RNA complexes and the dynamics of SG formation.
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Publication
Journal: Fitoterapia
March/3/2019
Abstract
Six new neolignans, sinensiols B-G (1-6), together with three known analogues (7-9) were isolated from the whole plant of Selaginella sinensis. Their planar structures were established by comprehensive spectroscopic analyses including 1D, 2D NMR, IR and HRESIMS data. The absolute configurations of new compounds were elucidated by comparing their experimental CD spectra with known ones and using the reversed helicity rule for the 1Lb band ECD of dihydrobenzofuran neolignans. Sinensiols A-D (7, 1-3) belong to sesquilignan with a dimer of dihydrobenzo[b]furan moiety. The potential precursors of sinensiols A, B, D were also reported in this paper. In addition, all new compounds were screened for their cytotoxicity against A549 and HepG2 human cancer cell lines, and they didn't show inhibition on the growth of cancer cells.
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