Bringing vascularization into glioblastoma in vitro models
Journal: 2021/December - Trends in Molecular Medicine
Tumor blood vessels create optimal conditions for glioblastoma (GBM) growth and therapy resistance. Therefore, tissue engineering techniques evolved towards allowing its inclusion in preclinical in vitro GBM models. In comparison with conventional ones, less representative of tumor biology, these new tools might significantly improve GBM treatment, contributing to a higher throughput screening in drug research and to the clinical translation of these therapies.
Keywords: glioblastoma; in vitro models; neovascularization; perivascular niche; tissue engineering.
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