Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.
Journal: 1983/September - Nature
ISSN: 0028-0836
PUBMED: 6308472
Abstract:
Transfection of embryo fibroblasts by a human ras oncogene does not convert them into tumour cells unless the fibroblasts are established and immortalized before transfection. The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.
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