Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells.
Journal: 2004/May - The Lancet
ISSN: 1474-547X
Abstract:
Adult bone-marrow-derived mesenchymal stem cells are immunosuppressive and prolong the rejection of mismatched skin grafts in animals. We transplanted haploidentical mesenchymal stem cells in a patient with severe treatment-resistant grade IV acute graft-versus-host disease of the gut and liver. Clinical response was striking. The patient is now well after 1 year. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.
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