The nuclear factor NF-kappaB pathway in inflammation.
Journal: 2010/August - Cold Spring Harbor perspectives in biology
ISSN: 1943-0264
Abstract:
The nuclear factor NF-kappaB pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-kappaB in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules. In this article, we describe how genetic evidence in mice has revealed complex roles for the NF-kappaB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway. NF-kappaB has long been considered the "holy grail" as a target for new anti-inflammatory drugs; however, these recent studies suggest this pathway may prove a difficult target in the treatment of chronic disease. In this article, we discuss the role of NF-kappaB in inflammation in light of these recent studies.
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Cold Spring Harb Perspect Biol 1(6): a001651

The Nuclear Factor NF-κB Pathway in Inflammation

Inflammation Biology Group, Centre d’Immunologie Marseille-Luminy, Parc Scientifique de Luminy, Case 906, 13288 Marseille, France
Correspondence:rf.srm-vinu.lmic@ecnerwal
Inflammation Biology Group, Centre d’Immunologie Marseille-Luminy, Parc Scientifique de Luminy, Case 906, 13288 Marseille, France
Correspondence:rf.srm-vinu.lmic@ecnerwal

Abstract

The nuclear factor NF-κB pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-κB in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules. In this article, we describe how genetic evidence in mice has revealed complex roles for the NF-κB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway. NF-κB has long been considered the “holy grail” as a target for new anti-inflammatory drugs; however, these recent studies suggest this pathway may prove a difficult target in the treatment of chronic disease. In this article, we discuss the role of NF-κB in inflammation in light of these recent studies.

Abstract

NF-κB has long been considered a prototypical proinflammatory signaling pathway, largely based on the activation of NF-κB by proinflammatory cytokines such as interleukin 1 (IL-1) and tumor necrosis factor α (TNFα), and the role of NF-κB in the expression of other proinflammatory genes including cytokines, chemokines, and adhesion molecules, which has been extensively reviewed elsewhere. But inflammation is a complex physiological process and the role of NF-κB in the inflammatory response cannot be extrapolated from in vitro studies. In this article, we describe how genetic evidence in mice has revealed complex roles for the NF-κB pathway in inflammation.

Adapted from Tak and Firestein 2001.

Footnotes

Editors: Louis M. Staudt and Michael Karin

Additional Perspectives on NF-κB available at www.cshperspectives.org

Footnotes

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