The frequency and profile of neurology in black South African HIV infected (clade C) patients - a hospital-based prospective audit.
Journal: 2007/May - Journal of the Neurological Sciences
ISSN: 0022-510X
Abstract:
OBJECTIVE
To determine the frequency and spectrum of neurological illnesses in Black South African hospital-based HIV infected (clade C) patients.
METHODS
A prospective audit of 506 consecutive HIV infected medical inpatients at the Helen Joseph Hospital, Johannesburg, South Africa.
RESULTS
The patients had a mean age of 37 years; a male:female ratio of 1.2:1; a mean CD4 count of 107 cells/ml. Eighty four percent of patients had AIDS defining CD4 counts (less than 200 cells/ml). Seventy five percent of patients had a neurological illness. In 64% the neurological illness occurred in association with a non-neurological (systemic) illness. Eleven percent of patients had an isolated neurological illness. The predominant systemic illness was tuberculosis (TB), occurring with a frequency of 46%. The neurological spectrum in our patients was similar to that described in the literature, (clade B virus data) other than for a greater frequency of infectious illnesses.
CONCLUSIONS
The neurological profile of HIV infection is a function of the environment and the immunological state of the patient (CD4 count) rather than an influence of the clade.
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