Although rarely reported spontaneously, sexual dysfunction is frequent in patients with schizophrenia. Sexual dysfunctions may be related to schizophrenia, to neuroleptic use and to psychiatric comorbidities, especially depression and addiction. Sexual dysfunctions induced by antipsychotics are related to their effect on the adrenergic and dopaminergic histamine receptors, in particular their blockage of the dopaminergic receptors of the tuberoinfundibular tracts, which causes excess prolactin secretion.