Red Raspberry Polyphenols Attenuate High Fat Diet-Driven Activation of NLRP3 Inflammasome and its Paracrine Suppression of Adipogenesis via Histone Modifications.
Journal: 2019/December - Molecular Nutrition and Food Research
ISSN: 1613-4133
Abstract:
We aimed to investigate the mechanisms by which red raspberry (RR) polyphenolic fractions regulate obesity and inflammation with an emphasis on the crosstalk between adipose tissue macrophages (ATM) and adipocyte progenitors.C57BL/6 male mice were fed either a HF diet or a HF diet supplemented with a RR polyphenolic fraction from whole fruit, pulp, or seed. Supplementation with pulp significantly increased energy expenditure and reduced HF diet-induced obesity and insulin resistance. The pulp, and to a lesser extent, whole polyphenols decreased the recruitment of ATM, activation of the NLRP3 inflammasome and adipocyte hypertrophy, which was associated with epigenetic modulation of adipogenesis (e.g., H3K27Ac, H3K9Ac). Results from an IL-1β reporter assay in J774 macrophages recapitulated the inhibitory role of RR polyphenols on NLRP3 inflammasome activation. Using conditioned media from macrophages, we demonstrated that RR polyphenols reversed the IL-1β-mediated epigenetic suppression of H3K27Ac in adipocyte progenitor cells.RR polyphenols from pulp and whole fruit serve as an inhibitor for NLRP3 inflammasome activation and an epigenetic modifier to regulate adipogenesis, which confers resistance against diet-induced obesity and metabolic dysfunction. This article is protected by copyright. All rights reserved.
Relations:
Citations
(1)
Diseases
(4)
Drugs
(1)
Genes
(1)
Organisms
(1)
Processes
(3)
Anatomy
(4)
Affiliates
(1)
Similar articles
Articles by the same authors
Discussion board
Collaboration tool especially designed for Life Science professionals.Drag-and-drop any entity to your messages.