Monocyte chemoattractant protein-1 (MCP-1): an overview.
Journal: 2009/November - Journal of Interferon and Cytokine Research
ISSN: 1557-7465
Abstract:
Chemokines constitute a family of chemoattractant cytokines and are subdivided into four families on the basis of the number and spacing of the conserved cysteine residues in the N-terminus of the protein. Chemokines play a major role in selectively recruiting monocytes, neutrophils, and lymphocytes, as well as in inducing chemotaxis through the activation of G-protein-coupled receptors. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines that regulate migration and infiltration of monocytes/macrophages. Both CCL2 and its receptor CCR2 have been demonstrated to be induced and involved in various diseases. Migration of monocytes from the blood stream across the vascular endothelium is required for routine immunological surveillance of tissues, as well as in response to inflammation. This review will discuss these biological processes and the structure and function of CCL2.
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J Interferon Cytokine Res 29(6): 313-326

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania.
Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania.
Corresponding author.
Address reprint requests or correspondence to: Bassel E. Sawaya, PhD, Department of Neurology, Temple University School of Medicine, 3400 N Broad Street, Room #201 OMS, Philadelphia, PA 19140, Tel: 215-707-5446 (office), 215-707-8417 (Lab), Fax: 215-707-5948. E-mail:ude.elpmet@ayawas
Current affiliation: Department of Neurology, Laboratory of Molecular Virology, Temple University School of Medicine, Philadelphia, Pennsylvania.
Address reprint requests or correspondence to: Bassel E. Sawaya, PhD, Department of Neurology, Temple University School of Medicine, 3400 N Broad Street, Room #201 OMS, Philadelphia, PA 19140, Tel: 215-707-5446 (office), 215-707-8417 (Lab), Fax: 215-707-5948. E-mail:ude.elpmet@ayawas
Received 2008 Mar 9; Accepted 2008 Dec 5.

Abstract

Chemokines constitute a family of chemoattractant cytokines and are subdivided into four families on the basis of the number and spacing of the conserved cysteine residues in the N-terminus of the protein. Chemokines play a major role in selectively recruiting monocytes, neutrophils, and lymphocytes, as well as in inducing chemotaxis through the activation of G-protein-coupled receptors. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines that regulate migration and infiltration of monocytes/macrophages. Both CCL2 and its receptor CCR2 have been demonstrated to be induced and involved in various diseases. Migration of monocytes from the blood stream across the vascular endothelium is required for routine immunological surveillance of tissues, as well as in response to inflammation. This review will discuss these biological processes and the structure and function of CCL2.

Abstract
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