Is dietary vitamin B intake associated with weight disorders in children and adolescents? The weight disorders survey of the CASPIAN-IV Study.
Journal: 2019/November - Health Promotion Perspectives
ISSN: 2228-6497
Abstract:
Background: Weight disorders are highly prevalent at the global level. Vitamin B groups are clearly involved in intracellular mechanisms, energy equation, and weight gain. The present study aims to evaluate the association of dietary vitamin B intake and obesity in a large pediatric population. Methods: This cross-sectional study was conducted among children and adolescents, aged 6-18years, living in urban and rural areas of 30 provinces of Iran. The BMI-for-age classifications were as follow: percentile <0.1, (emaciated), 0.1 ≤percentile <2.35 (thin), 2.35 ≤percentile≤84.1 (normal), 84.1 <percentile ≤97.7 (overweight), 97.1 <percentile (obese). A valid 168-item semi-quantitative Food Frequency Questionnaire (FFQ) was used to assess the usual dietary intake including vitamin B. Results: Out of 5606 children and adolescents participated (mean age: 11.62, SD: 3.32),46.8% were girls. The intake of thiamin, pyridoxine, niacin and pantothenic acid increased the likelihood of obesity, compared with the normal-weight group. Odds ratios (ORs) (95% CI) of obesity for vitamin B1, B3, B5, and B6 were 1.32 (1.14-1.53), 1.01 (1.00-1.02), 1.04 (1.00-1.08),and 1.20 (1.04-1.38), respectively. Riboflavin, cyanocobalamin, biotin and folic acid did not have any significant association with weight disorders (B2: OR=1.09, 95% CI =0.99-1.20); B12:OR=1.00, 95% CI=0.98-1.03; B8: OR=1.00, 95% CI=0.99-1.00 B9: OR=1.00, 95% CI=1.00-1.00). Conclusion: The current study showed a significant correlation between consumption of vitamin B group and increased risk of excess weight.
Relations:
Content
References
(38)
Diseases
(3)
Conditions
(3)
Drugs
(27)
Processes
(1)
Affiliates
(3)
Similar articles
Articles by the same authors
Discussion board
Health Promot Perspect 9(4): 299-306

Is dietary vitamin B intake associated with weight disorders in children and adolescents? The weight disorders survey of the CASPIAN-IV Study

Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Diseases, Isfahan University of Medical Sciences, Isfahan, Iran
Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
Department of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Department of Epidemiology, Provincial Health Center, Mazandaran University of Medical Sciences, Sari, Iran
Massachusetts College of Pharmacy and Health Sciences, Boston, USA
Corresponding Author: Roya Kelishadi, Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Diseases, Isfahan University of Medical Sciences, Isfahan, Iran. Postal Code: 81746-73461, Tel: +989131161496, Fax: +9831-33866266, Email: ri.ca.ium.dem@idahsilek
Received 2019 Apr 5; Accepted 2019 Aug 22.
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: Weight disorders are highly prevalent at the global level. Vitamin B groups are clearly involved in intracellular mechanisms, energy equation, and weight gain. The present study aims to evaluate the association of dietary vitamin B intake and obesity in a large pediatric population.

Methods: This cross-sectional study was conducted among children and adolescents, aged 6-18years, living in urban and rural areas of 30 provinces of Iran. The BMI-for-age classifications were as follow: percentile <0.1, (emaciated), 0.1 ≤percentile <2.35 (thin), 2.35 ≤percentile≤84.1 (normal), 84.1 <percentile ≤97.7 (overweight), 97.1 <percentile (obese). A valid 168-item semi-quantitative Food Frequency Questionnaire (FFQ) was used to assess the usual dietary intake including vitamin B.

Results: Out of 5606 children and adolescents participated (mean age: 11.62, SD: 3.32),46.8% were girls. The intake of thiamin, pyridoxine, niacin and pantothenic acid increased the likelihood of obesity, compared with the normal-weight group. Odds ratios (ORs) (95% CI) of obesity for vitamin B1, B3, B5, and B6 were 1.32 (1.14-1.53), 1.01 (1.00-1.02), 1.04 (1.00-1.08),and 1.20 (1.04-1.38), respectively. Riboflavin, cyanocobalamin, biotin and folic acid did not have any significant association with weight disorders (B2: OR=1.09, 95% CI =0.99-1.20); B12:OR=1.00, 95% CI=0.98-1.03; B8: OR=1.00, 95% CI=0.99-1.00 B9: OR=1.00, 95% CI=1.00-1.00).

Conclusion: The current study showed a significant correlation between consumption of vitamin B group and increased risk of excess weight.

Keywords: Obesity, Overweight, Vitamin B
Abstract

Abbreviation: RDA, recommended daily allowance.

Note: Values are mean (SD).

Comparison of the mean intakes of B vitamins among BMI categories using Kruskal-Wallis test.

Note: Values are OR (95% CI).

Model 1: Analyzed by multinomial logistic regression adjusted for age and energy intake (kcal) as covariates.

Model 2: Analyzed by multinomial logistic regression adjusted for age, energy intake (kcal), education, physical activity, and family size as covariates. (*P < 0.05, **P < 0.01, ***P<0.001).

Note: Values are OR (95% CI).

Model 1: Analyzed by multinomial logistic regression adjusted for age and energy intake (kcal) as covariates.

Model 2: Analyzed by multinomial logistic regression adjusted for age, energy intake (kcal), education, physical activity, and family size as covariates. (*P < 0.05, **P < 0.01, ***P<0.001).

Notes

Citation: Taleban R, Heidari-Beni M, Qorbani M, Motlagh ME, Fazel-Tabar Malekshah A, Moafi M, et al. Is dietary vitamin B intake associated with weight disorders in children and adolescents? The weight disorders survey of the CASPIAN-IV Study. Health Promot Perspect. 2019;9(4):290-306. doi: 10.15171/hpp.2019.41.

Notes

References

  • 1. Grossman DC, Bibbins-Domingo K, Curry SJ, Barry MJ, Davidson KW, Doubeni CA. et al. Screening for obesity in children and adolescents: US Preventive Services Task Force recommendation statement. JAMA. 2017;317(23):2417–26. doi: 10.1001/jama.2017.6803.] [[PubMed]
  • 2. Tenfold increase in childhood and adolescent obesity in four decades: new study by Imperial College London and WHOAvailable from: . Accessed 10 October 2019.
  • 3. Motlagh ME, Ziaodini H, Qorbani M, Taheri M, Aminaei T, Goodarzi A. et al. Methodology and early findings of the fifth survey of childhood and adolescence surveillance and prevention of adult noncommunicable disease: The caspian-v study. Int J Prev Med. 2017;8:4. doi: 10.4103/2008-7802.198915.] [
  • 4. Abarca-Gómez L, Abdeen ZA, Hamid ZA, Abu-Rmeileh NM, Acosta-Cazares B, Acuin C. et al. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128· 9 million children, adolescents, and adults. Lancet. 2017;390(10113):2627–42. doi: 10.1016/S0140-6736(17)32129-3.] [
  • 5. Budnik A, Henneberg MWorldwide increase of obesity is related to the reduced opportunity for natural selection. PloS One. 2017;12(1):e0170098. doi: 10.1371/journal.pone.0170098.] [[Google Scholar]
  • 6. Williams EP, Mesidor M, Winters K, Dubbert PM, Wyatt SBOverweight and obesity: prevalence, consequences, and causes of a growing public health problem. Curr Obes Rep. 2015;4(3):363–70. doi: 10.1007/s13679-015-0169-4.] [[PubMed][Google Scholar]
  • 7. Arroyo-Johnson C, Mincey KDObesity epidemiology worldwide. Gastroenterol Clin North Am. 2016;45(4):571–9. doi: 10.1016/j.gtc.2016.07.012.] [[Google Scholar]
  • 8. Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C. et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9945):766–81. doi: 10.1016/S0140-6736(14)60460-8.] [
  • 9. Damms-Machado A, Weser G, Bischoff SCMicronutrient deficiency in obese subjects undergoing low calorie diet. Nutr J. 2012;11(1):34. doi: 10.1186/1475-2891-11-34.] [[Google Scholar]
  • 10. Via MThe malnutrition of obesity: micronutrient deficiencies that promote diabetes. ISRN Endocrinol. 2012;2012:103472. doi: 10.5402/2012/103472.] [[Google Scholar]
  • 11. Asfaw AMicronutrient deficiency and the prevalence of mothers’ overweight/obesity in Egypt. Econ Hum Biol. 2007;5(3):471–83. doi: 10.1016/j.ehb.2007.03.004.] [[PubMed][Google Scholar]
  • 12. Astrup A, Bugel SMicronutrient deficiency in the aetiology of obesity. Int J Obes. 2010;34(6):947–9. doi: 10.1038/ijo.2010.81.] [[PubMed][Google Scholar]
  • 13. Schulze KJ, Christian P, Wu LS, Arguello M, Cui H, Nanayakkara-Bind A. et al. Micronutrient deficiencies are common in 6-to 8-year-old children of rural Nepal, with prevalence estimates modestly affected by inflammation. J Nutr. 2014;144(6):979–87. doi: 10.3945/jn.114.192336.] [
  • 14. Zhou S-S, Zhou YExcess vitamin intake: An unrecognized risk factor for obesity. World J Diabetes. 2014;5(1):1. doi: 10.4239/wjd.v5.i1.1.] [[Google Scholar]
  • 15. Aasheim ET, Hofsø D, Hjelmesæth J, Birkeland KI, Bøhmer TVitamin status in morbidly obese patients: a cross-sectional study. Am J Clin Nutr. 2008;87(2):362–9. doi: 10.1093/ajcn/87.2.362.] [[PubMed][Google Scholar]
  • 16. Zhou SS, Li D, Chen NN, Zhou YVitamin paradox in obesity: deficiency or excess? World J Diabetes. 2015;6(10):1158–67. doi: 10.4239/wjd.v6.i10.1158.] [[Google Scholar]
  • 17. Zhou SS, Li D, Zhou YM, Sun WP, Liu QGB-vitamin consumption and the prevalence of diabetes and obesity among the US adults: population based ecological study. BMC Public Health. 2010;10:746. doi: 10.1186/1471-2458-10-746.] [[Google Scholar]
  • 18. Kelishadi R, Majdzadeh R, Motlagh M-E, Heshmat R, Aminaee T, Ardalan G. et al. Development and evaluation of a questionnaire for assessment of determinants of weight disorders among children and adolescents: The Caspian-IV study. Int J Prev Med. 2012;3(10):699.
  • 19. WHO. Growth reference 5-19 years. WHO; 2019. Available from: . Accessed 10 October 2019.
  • 20. Yoo EGWaist-to-height ratio as a screening tool for obesity and cardiometabolic risk. Korean J Pediatr. 2016;59(11):425. doi: 10.3345/kjp.2016.59.11.425.] [[Google Scholar]
  • 21. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington (DC): The National Academies Press; 2019.
  • 22. Liu M, Alimov A, Wang H, Frank JA, Katz W, Xu M. et al. Thiamine deficiency induces anorexia by inhibiting hypothalamic AMPK. Neuroscience. 2014;267:102–13. doi: 10.1016/j.neuroscience.2014.02.033.] [
  • 23. Saad L, Silva LF, Banzato CE, Dantas CR, Garcia CAnorexia nervosa and Wernicke-Korsakoff syndrome: a case report. J Med Case Rep. 2010;4(1):217. doi: 10.1186/1752-1947-4-217.] [[Google Scholar]
  • 24. Kerns JC, Arundel C, Chawla LSThiamin deficiency in people with obesity. Adv Nutr. 2015;6(2):147–53. doi: 10.3945/an.114.007526.] [[Google Scholar]
  • 25. Patrini C, Griziotti A, Ricciardi LObese individuals as thiamin storers. Int J Obes. 2004;28(7):920–4. doi: 10.1038/sj.ijo.0802638.] [[PubMed][Google Scholar]
  • 26. Li D, Sun WP, Zhou YM, Liu QG, Zhou SS, Luo N. et al. Chronic niacin overload may be involved in the increased prevalence of obesity in US children. World J Gastroenterol. 2010;16(19):2378–87. doi: 10.3748/wjg.v16.i19.2378.] [
  • 27. Mazur-Bialy AI, Pocheć EVitamin B2 deficiency enhances the pro-inflammatory activity of adipocyte, consequences for insulin resistance and metabolic syndrome development. Life Sci. 2017;178:9–16. doi: 10.1016/j.lfs.2017.04.010.] [[PubMed][Google Scholar]
  • 28. Freisling H, Pisa PT, Ferrari P, Byrnes G, Moskal A, Dahm CC. et al. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries. Eur J Nutr. 2016;55(6):2093–104. doi: 10.1007/s00394-015-1023-x.] [[PubMed]
  • 29. Schiffman S, Graham BTaste and smell perception affect appetite and immunity in the elderly. Eur J Clin Nutr. 2000;54(S3):S54. doi: 10.1038/sj.ejcn.1601026.] [[PubMed][Google Scholar]
  • 30. Donini LM, Savina C, Cannella CEating habits and appetite control in the elderly: the anorexia of aging. Int Psychogeriatr. 2003;15(1):73–87. doi: 10.1017/S1041610203008779.] [[PubMed][Google Scholar]
  • 31. Zhou SS, Zhou YSubstitution of whole grains for refined grains: a means to avoid excess B-vitamin intake. Am J Clin Nutr. 2017;106(3):946–7. doi: 10.3945/ajcn.117.157735.] [[PubMed][Google Scholar]
  • 32. Liu Z, Li P, Zhao ZH, Zhang Y, Ma ZM, Wang SXVitamin b6 prevents endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in apoe−/− mice fed with high-fat diet. J Diabetes Res. 2016;2016(3):1–8. doi: 10.1155/2016/1748065.] [[Google Scholar]
  • 33. Iglesia I, González-Gross M, Huybrechts I, De Miguel-Etayo P, Molnar D. et al. Associations between insulin resistance and three B-vitamins in European adolescents: the HELENA study. Nutr Hosp. 2017;34(3):566–71. doi: 10.20960/nh.559.] [[PubMed]
  • 34. Järvinen E, Ismail K, Muniandy M, Bogl L, Heinonen S, Tummers M. et al. Biotin-dependent functions in adiposity: a study of monozygotic twin pairs. Int J Obes. 2016;40(5):788–95. doi: 10.1038/ijo.2015.237.] [[PubMed]
  • 35. Maurice MS, Reinhardt L, Surinya KH, Attwood PV, Wallace JC, Cleland WW. et al. Domain architecture of pyruvate carboxylase, a biotin-dependent multifunctional enzyme. Science. 2007;317(5841):1076–9. doi: 10.1126/science.1144504.] [[PubMed]
  • 36. Thomas-Valdés S, Tostes MDGV, Anunciação PC, da Silva BP, Sant’Ana HMPAssociation between vitamin deficiency and metabolic disorders related to obesity. Crit Rev Food Sci Nutr. 2017;57(15):3332–43. doi: 10.1080/10408398.2015.1117413.] [[PubMed][Google Scholar]
  • 37. Levert KL, Waldrop GL, Stephens JMA biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis. J Biol Chem. 2002;277(19):16347–50. doi: 10.1074/jbc.C200113200.] [[PubMed][Google Scholar]
  • 38. Sheu WH, Chin HM, Lee WJ, Wan CJ, Su HY, Lang HFProspective evaluation of folic acid supplementation on plasma homocysteine concentrations during weight reduction: a randomized, double-blinded, placebo-controlled study in obese women. Life Sci. 2005;76(18):2137–45. doi: 10.1016/j.lfs.2004.12.002.] [[PubMed][Google Scholar]
  • 39. Li Z, Gueant-Rodriguez R-M, Quilliot D, Sirveaux M-A, Meyre D, Gueant JL. et al. Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity. Clin Nutr. 2018;37(5):1700–1706. doi: 10.1016/j.clnu.2017.07.008.] [[PubMed]
  • 40. Nguyen TTT, Tsujiguchi H, Kambayashi Y, Hara A, Miyagi S, Yamada Y. et al. Relationship between vitamin intake and depressive symptoms in elderly japanese individuals: differences with gender and body mass index. Nutrients. 2017;9(12):1319. doi: 10.3390/nu9121319.] [
  • 41. Xie R, Liu Y, Retnakaran R, MacFarlane A, Hamilton J, Smith G. et al. Maternal folate status and obesity/insulin resistance in the offspring: a systematic review. Int J Obes. 2016;40(1):1–9. doi: 10.1038/ijo.2015.189.] [[PubMed]
Collaboration tool especially designed for Life Science professionals.Drag-and-drop any entity to your messages.