First clinical inflammatory demyelinating events of the central nervous system in a population aged over 70 years: A multicentre study.

Cécile Dulau+11 authors

Journal: 2019/January - Multiple Sclerosis and Related Disorders

ISSN: 2211-0356

PUBMED: 30665072

DOI: 10.1016/j.msard.2018.12.016

Abstract:

Few data are available regarding patients with very late-onset inflammatory demyelinating events. (VLO-IDE).The aim of this study was to describe the clinical, biological, and radiological characteristics and aetiological diagnosis of very late first inflammatory demyelinating events of the central nervous system.We conducted a national descriptive retrospective multicentre study on a case series of patients aged >70 years at the time of VLO-IDE. Patients were recruited from a national call on behalf of the 'Société Francophone de la Sclérose en Plaques' (French Multiple Sclerosis Society).Twenty-five patients were referred (F:M sex ratio 2.1:1). The most frequent clinical impairment was a spinal cord deficit (23/25), usually severe (disability score, median EDSS 4.5 [2-9.5]). Spinal cord lesions were usually extensive, spanning at least three segments (11/25), and large brain lesions were also observed (lesions >20 mm in 6/25). The final aetiological diagnoses comprised multiple sclerosis (9/25), neuromyelitis optica spectrum disorders (7/25), neurosystemic lupus erythematosus (2/25), transverse myelitis without aetiological diagnosis (6/25) and optic neuritis (1/25).This study highlights a particular phenotype of first clinical inflammatory demyelinating events in predominantly female patients aged >70 years who have severe motor impairment with common longitudinal extensive myelitis and large and common very active radiological inflammatory lesions. Neuromyelitis optica spectrum disorders seem overrepresented.

Open in

PUBMED | DOI | Google Scholar | Wikipedia

Relations:

Diseases

(5)

Processes

(3)

Anatomy

(3)