Feverfew as a preventive treatment for migraine: a systematic review.
Journal: 1999/April - Cephalalgia
ISSN: 0333-1024
Abstract:
BACKGROUND
Feverfew is a popular herbal remedy advocated for the prevention of migraine.
OBJECTIVE
The aim of this systematic review was to look at the evidence for or against the clinical effectiveness of feverfew in migraine prevention.
METHODS
Literature searches were performed using the following databases: Medline, Embase, Biosis, CISCOM, and the Cochrane Library (all from their inception to April 1998).
METHODS
Only randomized, placebo-controlled, double-blind trials were included.
METHODS
All articles were read by two independent reviewers. Data were extracted in a predefined, standardized fashion. The methodological quality of all trials was evaluated using the Jadad score.
RESULTS
Five trials met the inclusion/exclusion criteria. The majority favor feverfew over placebo. Yet important caveats exist.
CONCLUSIONS
The clinical effectiveness of feverfew in the prevention of migraine has not been established beyond reasonable doubt.
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