Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis.
Journal: 1995/February - Infection and Immunity
ISSN: 0019-9567
PUBMED: 7529749
Abstract:
We have recently demonstrated that the macrophage L-arginine-dependent cytotoxic pathway effectively kills the virulent Erdman strain of Mycobacterium tuberculosis in vitro via the generation of toxic reactive nitrogen intermediates by the enzyme nitric oxide synthase. This report demonstrates that two distinct inhibitors of nitric oxide synthase (aminoguanidine and NG-monomethyl-L-arginine) render similar deleterious effects on tuberculous infection in mice, as assessed by mortality, bacterial burden, and pathological tissue damage, thus confirming the importance of reactive nitrogen intermediates in resistance against M. tuberculosis.
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Infect Immun 63(2): 736-740

Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis.

Abstract

We have recently demonstrated that the macrophage L-arginine-dependent cytotoxic pathway effectively kills the virulent Erdman strain of Mycobacterium tuberculosis in vitro via the generation of toxic reactive nitrogen intermediates by the enzyme nitric oxide synthase. This report demonstrates that two distinct inhibitors of nitric oxide synthase (aminoguanidine and NG-monomethyl-L-arginine) render similar deleterious effects on tuberculous infection in mice, as assessed by mortality, bacterial burden, and pathological tissue damage, thus confirming the importance of reactive nitrogen intermediates in resistance against M. tuberculosis.

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  • Beaven MA, Gordon JW, Jacobsen S, Severs WB. A specific and sensitive assay for aminoguanidine: its application to a study of the disposition of aminoguanidine in animal tissues. J Pharmacol Exp Ther. 1969 Jan;165(1):14–22. [PubMed] [Google Scholar]
  • Beckerman KP, Rogers HW, Corbett JA, Schreiber RD, McDaniel ML, Unanue ER. Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes. J Immunol. 1993 Feb 1;150(3):888–895. [PubMed] [Google Scholar]
  • Boockvar KS, Granger DL, Poston RM, Maybodi M, Washington MK, Hibbs JB, Jr, Kurlander RL. Nitric oxide produced during murine listeriosis is protective. Infect Immun. 1994 Mar;62(3):1089–1100.[PMC free article] [PubMed] [Google Scholar]
  • Chan J, Xing Y, Magliozzo RS, Bloom BR. Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J Exp Med. 1992 Apr 1;175(4):1111–1122.[PMC free article] [PubMed] [Google Scholar]
  • Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme IM. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med. 1993 Dec 1;178(6):2243–2247.[PMC free article] [PubMed] [Google Scholar]
  • Corbett JA, Tilton RG, Chang K, Hasan KS, Ido Y, Wang JL, Sweetland MA, Lancaster JR, Jr, Williamson JR, McDaniel ML. Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. Diabetes. 1992 Apr;41(4):552–556. [PubMed] [Google Scholar]
  • Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart TA. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science. 1993 Mar 19;259(5102):1739–1742. [PubMed] [Google Scholar]
  • Ding AH, Nathan CF, Stuehr DJ. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol. 1988 Oct 1;141(7):2407–2412. [PubMed] [Google Scholar]
  • Evans TG, Thai L, Granger DL, Hibbs JB., Jr Effect of in vivo inhibition of nitric oxide production in murine leishmaniasis. J Immunol. 1993 Jul 15;151(2):907–915. [PubMed] [Google Scholar]
  • Flynn JL, Chan J, Triebold KJ, Dalton DK, Stewart TA, Bloom BR. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med. 1993 Dec 1;178(6):2249–2254.[PMC free article] [PubMed] [Google Scholar]
  • Forrest CB, Forehand JR, Axtell RA, Roberts RL, Johnston RB., Jr Clinical features and current management of chronic granulomatous disease. Hematol Oncol Clin North Am. 1988 Jun;2(2):253–266. [PubMed] [Google Scholar]
  • Granger DL, Hibbs JB, Jr, Broadnax LM. Urinary nitrate excretion in relation to murine macrophage activation. Influence of dietary L-arginine and oral NG-monomethyl-L-arginine. J Immunol. 1991 Feb 15;146(4):1294–1302. [PubMed] [Google Scholar]
  • Green SJ, Nacy CA, Schreiber RD, Granger DL, Crawford RM, Meltzer MS, Fortier AH. Neutralization of gamma interferon and tumor necrosis factor alpha blocks in vivo synthesis of nitrogen oxides from L-arginine and protection against Francisella tularensis infection in Mycobacterium bovis BCG-treated mice. Infect Immun. 1993 Feb;61(2):689–698.[PMC free article] [PubMed] [Google Scholar]
  • Gregory SH, Wing EJ, Hoffman RA, Simmons RL. Reactive nitrogen intermediates suppress the primary immunologic response to Listeria. J Immunol. 1993 Apr 1;150(7):2901–2909. [PubMed] [Google Scholar]
  • Kamijo R, Harada H, Matsuyama T, Bosland M, Gerecitano J, Shapiro D, Le J, Koh SI, Kimura T, Green SJ, et al. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science. 1994 Mar 18;263(5153):1612–1615. [PubMed] [Google Scholar]
  • Kamijo R, Le J, Shapiro D, Havell EA, Huang S, Aguet M, Bosland M, Vilcek J. Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide. J Exp Med. 1993 Oct 1;178(4):1435–1440.[PMC free article] [PubMed] [Google Scholar]
  • Liew FY, Cox FE. Nonspecific defence mechanism: the role of nitric oxide. Immunol Today. 1991 Mar;12(3):A17–A21. [PubMed] [Google Scholar]
  • Liew FY, Millott S, Parkinson C, Palmer RM, Moncada S. Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine. J Immunol. 1990 Jun 15;144(12):4794–4797. [PubMed] [Google Scholar]
  • McDermott JR. Studies on the catabolism of Ng-methylarginine, Ng, Ng-dimethylarginine and Ng, Ng-dimethylarginine in the rabbit. Biochem J. 1976 Jan 15;154(1):179–184.[PMC free article] [PubMed] [Google Scholar]
  • Moncada S. The 1991 Ulf von Euler Lecture. The L-arginine: nitric oxide pathway. Acta Physiol Scand. 1992 Jul;145(3):201–227. [PubMed] [Google Scholar]
  • Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992 Sep;6(12):3051–3064. [PubMed] [Google Scholar]
  • Nathan CF, Hibbs JB., Jr Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol. 1991 Feb;3(1):65–70. [PubMed] [Google Scholar]
  • Paik WK, Abou-Gharbia M, Swern D, Lotlikar P, Kim S. Metabolism of NG-monomethyl-L-arginine. Can J Biochem Cell Biol. 1983 Aug;61(8):850–855. [PubMed] [Google Scholar]
  • Paik WK, Kim S, Hutchins MG, Swern D. Metabolism of NG-monomethyl-L-arginine: formation of NG-methylagmatine by Escherichia coli preparation. Can J Biochem. 1981 Feb;59(2):131–136. [PubMed] [Google Scholar]
  • Seguin MC, Klotz FW, Schneider I, Weir JP, Goodbary M, Slayter M, Raney JJ, Aniagolu JU, Green SJ. Induction of nitric oxide synthase protects against malaria in mice exposed to irradiated Plasmodium berghei infected mosquitoes: involvement of interferon gamma and CD8+ T cells. J Exp Med. 1994 Jul 1;180(1):353–358.[PMC free article] [PubMed] [Google Scholar]
Departments of Medicine, Albert Einstein College of Medicine, Bronx, New York.
Departments of Medicine, Albert Einstein College of Medicine, Bronx, New York.

Abstract

We have recently demonstrated that the macrophage L-arginine-dependent cytotoxic pathway effectively kills the virulent Erdman strain of Mycobacterium tuberculosis in vitro via the generation of toxic reactive nitrogen intermediates by the enzyme nitric oxide synthase. This report demonstrates that two distinct inhibitors of nitric oxide synthase (aminoguanidine and NG-monomethyl-L-arginine) render similar deleterious effects on tuberculous infection in mice, as assessed by mortality, bacterial burden, and pathological tissue damage, thus confirming the importance of reactive nitrogen intermediates in resistance against M. tuberculosis.

Abstract
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