Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development.
Journal: 2017/August - Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Abstract:
GAS2L3 is a recently identified cytoskeleton-associated protein that interacts with actin filaments and tubulin. The in vivo function of GAS2L3 in mammals remains unknown. Here, we show that mice deficient in GAS2L3 die shortly after birth because of heart failure. Mammalian cardiomyocytes lose the ability to proliferate shortly after birth, and further increase in cardiac mass is achieved by hypertrophy. The proliferation arrest of cardiomyocytes is accompanied by binucleation through incomplete cytokinesis. We observed that GAS2L3 deficiency leads to inhibition of cardiomyocyte proliferation and to cardiomyocyte hypertrophy during embryonic development. Cardiomyocyte-specific deletion of GAS2L3 confirmed that the phenotype results from the loss of GAS2L3 in cardiomyocytes. Cardiomyocytes from Gas2l3-deficient mice exhibit increased expression of a p53-transcriptional program including the cell cycle inhibitor p21. Furthermore, loss of GAS2L3 results in premature binucleation of cardiomyocytes accompanied by unresolved midbody structures. Together these results suggest that GAS2L3 plays a specific role in cardiomyocyte cytokinesis and proliferation during heart development.
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Med J Armed Forces India 55(2): 148

RADIOLOGICAL QUIZ

Classified Specialist, Department of Radiodiagnosis, Command Hospital (Southern Command), Pune 411 040
Addl Director General Medical Services (Army), Office of DGMS (Army), Army Headquarters, L Block, New Delhi 110001
Graded Specialist, Radiology, MH Jalandhar Cantt
Senior Advisor, Department of Radiodiagnosis, Command Hospital (Southern Command), Pune 411 040

A 35-years-old soldier presented with chronic pulmonary pathology undergoing treatment. All routine investigations were within normal limits except for raised erythrocyte sedimentation rate. Plain radiograph of the chest (Fig 1) and CT chest (Fig 2) were performed.

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PA view chest shows the lesion in right upper zone

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HRCT chest through right upper lobe in supine position

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