A new phenolic glycoside from the Idesia polycarpa Maxim. leaves.
Journal: 2018/December - Natural Product Research
ISSN: 1478-6427
Abstract:
Phytochemical investigation on the ethyl acetate extract of <i>Idesia polycarpa</i> Maxim. Leaves led to the isolation of four phenolic glycoside isomers (<b>1-4</b>). Compound <b>2</b> appeared to be new reported phenolic glycoside, while compound <b>1</b> was the first time isolated from the titled species. Their structures were established by IR, UV, HRESI-MS and 1D and 2D NMR spectroscopies analysis and comparison of spectral data with previously reported data. The compounds <b>3</b> and <b>4</b> showed stronger activity of scavenging the DPPH free radical than the other two compounds, while the compounds <b>1</b> and <b>2</b> showed a significant activity of scavenging the ABTS free radical. Compounds <b>2</b> and <b>4</b> exhibited stronger cytotoxicity against HepG2 cell lines compared to compounds <b>1</b> and <b>3</b>. Moreover, compound <b>3</b> presented the highest cytotoxicity against MCF cell lines with IC<sub>50</sub> value of 37.17 ± 0.26 μg/mL than compounds <b>1</b>, <b>2</b> and <b>4</b>.
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