The gray-scale display which is driven by PWM (pulse width modulation) in TFT (thin film transistor) electrowetting displays (EWDs) has some shortcomings, such as large amplitude of oil oscillation in pixels and slow response speed for displaying gray scale. In this paper, an amplitude-frequency mixed modulation driving system is proposed to improve the response speed of driving gray scale and enhance the oil stability when the gray scale is displayed. In the initial stage of the driving process, the oil is driven by a high voltage to close to the target luminance, and the driving voltage is then decreased to stabilize the oil. The electrowetting hysteresis curve was used to calculate the relation model between the driving voltage and the luminance of the pixel in the system, and the driving voltage value of the pixel at each driving stage was then set to make the oil precisely and rapidly stabilize at the target luminance value. In the output driving platform, the amplitude-frequency mixed modulation is realized based on the source IC, which was used to realize digital-to-analog conversion. An 8 inch EWD was tested using an Admesy colorimeter, and the experimental results show that the pixel response time is reduced by 70% and the gray-scale oscillation is reduced by 80%.